COllaboration REsearch on Chronic Cough (COREC): a French Multicenter Database

NCT04882943 | Terminated

• 2 other identifiers: RC31/20/03782020-A02774-35
• Study Type: observational
• Target: 178
• Locations: 1 country
• Sites: 6

Brief Summary

Chronic cough (TC), defined by a duration exceeding 8 weeks, is a particularly frequent symptom with a prevalence observed at 9.6% 1. Chronic cough is the cause of a major handicap for patients with a impact on their quality of life 2. Although CT is common, management is often delicate and complex. In studies, asthma, gastroesophageal reflux disease, posterior flushing, rhino-sinusitis, or taking tussigenic medications are common causes of chronic coughs. However, chronic refractory or unexplained cough, which corresponds to cough for which no cause has been found or the treatments directed against the cause of the cough have not made it possible to resolve the cough, is a real problem in practice. nick3. There is currently no prospective data in France on the characteristics of chronic cough (etiologies, response to treatment) and the percentage of refractory cough. The aim of the study is to constitute a French prospective multicenter hospital cohort of chronic cough patients in order to identify, for the first time in France in a prospective and multicenter manner, the frequency of patients with refractory cough among chronic cough patients.

Conditions

Refractory Chronic Cough

Outcome Measures

Primary Outcomes (1)

• French prospective multicenter hospital cohort of chronic cough patients (requency of patients with unexplained or refractory chronic cough (URCC)

  set up a French prospective multicenter hospital cohort of chronic cough patients in order to identify the frequency of patients with unexplained or refractory chronic cough (URCC) for the first time in France

  24 months

Study Arms (1)

patients with unexplained or refractory chronic cough

Patients with cough lasting for more than 8 weeks (duration corresponding to the definition of chronic cough)

Other: questionnaires

Interventions

questionnaires OTHER

Quality of life questionnaires

patients with unexplained or refractory chronic cough

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

chronic cough patients

You may qualify if:

• Age ≥18 years old
• Consultation motivated by cough lasting for more than 8 weeks (duration corresponding to the definition of chronic cough)
• Patient covered by a National Health Insurance

You may not qualify if:

• Active smoker or recent smoking cessation (within the past 6 months)
• Intake of medications causing cough (the patient can be included 4 weeks after treatment discontinuation if cough persists)
• Pregnant or breast-feeding women
• Upper or lower respiratory tract infection within the past 4 weeks
• Active lung disease (such as interstitial lung disease, lung cancer, abnormal dilation of the bronchi).
• History of chronic bronchitis.
• Current treatment with an angiotensin converting enzyme (ACE) inhibitor
• History of cancer within the past 5 years or active cancer (excluding cutaneous squamous-cell carcinoma).
• Person not fluent in French
• Adult not able to express his/her consent verbally
• Patient refusal

Sponsors & Collaborators

• University Hospital, Toulouse: lead
• MSD France: collaborator

Study Sites (6)

CHU de Besançon

Besançon, France

Location

CHU de Bordeaux

Bordeaux, France

Location

CH de Libourne

Libourne, France

Location

AP-HP Bichat

Paris, France

Location

UHToulouse

Toulouse, 31059, France

Location

CHU de Tours

Tours, France

Location

Related Publications (1)

• Guilleminault L, Dupin C, Portel L, Zysman M, Flament T, Roux P, Costa N, Mounie M. The Healthcare Resource Utilization of Patients with Refractory Chronic Cough Compared to Those with Non-Refractory Chronic Cough. Lung. 2025 Oct 4;203(1):97. doi: 10.1007/s00408-025-00853-z.

  PMID: 41046288 RESULT

MeSH Terms

Conditions

Chronic Cough

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Cough; Respiration Disorders; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Laurent GUILLEMINAULT

  University Hospital, Toulouse

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 6, 2021
• First Posted: May 12, 2021
• Study Start: June 22, 2021
• Primary Completion: November 25, 2025
• Study Completion: April 2, 2026
• Last Updated: April 14, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

FR (6)