Study Stopped
DISCO-main reached 1006 patients and the current DISCO-no-COMA was slow in enrollment so steering committee decided to stop enrollment
Direct or Subacute Coronary Angiography in Patients With Out of Hospital Cardiac Arrest Without Coma.
DISCO-noCOMA
1 other identifier
interventional
212
2 countries
7
Brief Summary
In patients with Out-of-Hospital Cardiac arrest who achieves Return Of Spontaneous Circulation (ROSC) The investigators want to evaluate whether there is a benefit from acute Angiography compared to subacute (12-24 hours) Angiography
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started May 2021
Longer than P75 for not_applicable
7 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 30, 2021
CompletedStudy Start
First participant enrolled
May 3, 2021
CompletedFirst Posted
Study publicly available on registry
May 6, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 22, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
April 22, 2026
CompletedApril 28, 2026
April 1, 2026
5 years
April 30, 2021
April 22, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Major Adverse Cardiovascular Events
Mortality, cardiogenic shock or recurrent cardiac arrest
30-day
Secondary Outcomes (24)
Mortality
30-day and 1-year and 5-year
Cardiogenic shock
30-day and 1-year
Recurrent cardiac arrest
30-day and 5-year
Revascularization
30-day and 1-year
Cerebral Performance Category score
30-day and 6-month
- +19 more secondary outcomes
Study Arms (2)
Acute CAG
ACTIVE COMPARATORThe patient is triaged directly to the catheterization laboratory for acute evaluation including ECHO, acute CAG and PCI if indicated according to guidelines.
Subacute CAG
NO INTERVENTIONThe patient is triaged to the coronary care unit (CCU) for rhythm surveillance, and additional diagnostics, and in case there is found indication for CAG, it is planned for the coming day in daytime (12-24 hours after cardiac arrest). Revascularization is performed if indicated according to guidelines.
Interventions
The patient is triaged directly to the catheterization laboratory for acute evaluation including ECHO, acute CAG and PCI if indicated according to guidelines.
Eligibility Criteria
You may qualify if:
- Witnessed Cardiac Arrest
- ROSC
- CAG possible within 120 minutes
- Glasgow coma scale \>8
You may not qualify if:
- Age \< 18 years
- Obvious non-cardiac cause for the arrest
- Terminal illness
- STEMI
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Aarhus University Hospital Skejbylead
- Aalborg University Hospitalcollaborator
- Odense University Hospitalcollaborator
- Rigshospitalet, Denmarkcollaborator
Study Sites (7)
Aalborg University Hospital
Aalborg, Denmark, Denmark
Rigshospitalet
Copenhagen, Denmark, Denmark
Odense University Hospital
Odense, Denmark, 5000, Denmark
Christian Juhl Terkelsen
Aarhus, 8200, Denmark
Department of cardiology, Aarhus University Hospital in Skejby
Aarhus, 8200, Denmark
Catharina Zeikenhuis
Eindhoven, 5623, Netherlands
Radboud Universitair Medisch Centrum
Nijmegen, 6525, Netherlands
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal investigator
Study Record Dates
First Submitted
April 30, 2021
First Posted
May 6, 2021
Study Start
May 3, 2021
Primary Completion
April 22, 2026
Study Completion
April 22, 2026
Last Updated
April 28, 2026
Record last verified: 2026-04