Structural Cartography of the Insula in Temporal Epilepsy Patients

NCT04871555 | Unknown

• 1 other identifier: 2020PI218
• Study Type: observational
• Target: 115
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate insula structural connectivity in temporal epilepsy patients. Insula being at the interface of frontal, parietal, occipital and temporal lobes, its structural organization reflects the brain function. We hypothetize that insular structural organization will be different according to the different subtypes of temporal epilepsy.

Conditions

Epilepsy, Temporal Lobe; MRI Scans

Keywords

structural connectivity; insula; temporal lobe epilepsy

Outcome Measures

Primary Outcomes (1)

• cartography of insula in temporal epilepsy patients

  Compared with healthy group, definition of different patterns of insular structural connectivity in epileptic patients

  1 year after the last inclusion

Secondary Outcomes (1)

• Correlation structural cartography and electroclinical data

  1 year after the last inclusion

Study Arms (6)

mesio-temporal epilepsy

patients suffering from mesiotemporal epilepsy type

Other: MRI

basal temporal epilepsy

patients suffering from basal temporal epilepsy type

Other: MRI

temporal lateral epilepsy

patients suffering from temporal lateral epilepsy type

Other: MRI

operculo insular epilepsy

patients suffering from operculo insular epilepsy type

Other: MRI

temporo-insular epilepsy

patients suffering from temporo- insular epilepsy type

Other: MRI

healthy subjects

non epileptic patients

Other: MRI

Interventions

MRI OTHER

structural imaging

basal temporal epilepsy; healthy subjects; mesio-temporal epilepsy; operculo insular epilepsy; temporal lateral epilepsy; temporo-insular epilepsy

Eligibility Criteria

• Age: 15 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

temporal epilepsy patients and healthy subjects healthy subjects will be selected in the healthy cohort of Nguyen G-Dang (Ghaziri et al., 2017)

You may qualify if:

• epileptic patients: temporal epilepsy or temporal plus epilepsy (temporomesial epilepsy, basal temporal epilepsy, mesio lateral or lateral epilepsy, temporo insular epilepsy, operculo insular epilepsy)
• patients who underwent video EEG monitoring with recorded seizures (at least one)
• patients who underwent a brain MRI with DTI sequence before epilepsy surgery
• patients who did not refuse the use of their clinical and MRI data for this study

You may not qualify if:

• patients younger than 15 years old
• patients with previous brain surgery (before MRI)
• uncompleted MRI sequences (DTI, T1 anatomical)

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead
• Centre de Recherche du Centre Hospitalier de l'Université de Montréal: collaborator
• University Hospital, Lille: collaborator
• Hospices Civils de Lyon: collaborator

Study Sites (1)

Central Hospital nancy

Nancy, 54000, France

Location

MeSH Terms

Conditions

Epilepsy, Temporal Lobe

Condition Hierarchy (Ancestors)

Epilepsies, Partial; Epilepsy; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Epileptic Syndromes

Study Officials

• Louise Tyvaert, MD PHD

  CHRU Nancy, CRAN UMR 7039 Université de Lorraine

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Louise Tyvaert, Pr

CONTACT

33383857723; l.tyvaert@chru-nancy.fr

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: April 29, 2021
• First Posted: May 4, 2021
• Study Start: June 1, 2021
• Primary Completion: April 30, 2022
• Study Completion: December 31, 2022
• Last Updated: May 4, 2021

Record last verified: 2021-04

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)