Effects of Breathing Patterns on Post-prandial Vascular Function

NCT04864184 | Completed

• 1 other identifier: 7374
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is investigate the effects of two different breathing styles on postprandial vascular function and oxidative stress markers. Participants will complete 2 breathing conditions in random order.

Conditions

Healthy

Keywords

Breathing; Yogic breathing

Outcome Measures

Primary Outcomes (2)

• Change in flow-mediated dilation

  Ultrasound-derived images of the brachial artery pre- and post-suprasystolic cuff inflation will yield flow-mediated dilation values. These are indices are endothelium-dependent vasodilation.

  At baseline and at again 1, 2, 4 hours post high-fat meal consumption

• Changes in oxidative stress

  Blood draws will be performed and samples will be processed and stored for future biochemical analysis of blood markers indicative of oxidative stress.

  Once at baseline and again at 1, 2, and 4 hours post high-fat meal consumption.

Study Arms (1)

Breathing intervention

EXPERIMENTAL

Participants will complete 2-minute breathing exercises following the Breathing App every 15 minutes during a 4-hour postprandial period following high-fat meal consumption.

Behavioral: Normal physiologic rate breathing; Behavioral: Slow breathing

Interventions

Normal physiologic rate breathing BEHAVIORAL

2-minute breathing exercises will be completed every 15 minutes.

Breathing intervention

Slow breathing BEHAVIORAL

2-minute breathing exercises will be completed every 15 minutes.

Breathing intervention

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male participants ages 18-35 years

You may not qualify if:

• Infection within the previous 4 weeks
• Renal disorders
• Any cardiovascular disorders such as prior myocardial infarction, known coronary artery disease, personal history of stroke, heart failure, cardiac arrhythmias
• Chronic obstructive pulmonary disease
• Diabetes
• Inflammatory bowel disease
• HIV, rheumatoid arthritis, chronic or other inflammatory conditions
• Currently taking steroids or other anti-inflammatory medications
• Current use of nonsteroidal anti-inflammatory drugs
• Smoking
• Stage 2 hypertension or higher (systolic BP of 140 mm Hg or higher and/or diastolic BP of 90 mm Hg or higher)
• Lactose intolerance

Sponsors & Collaborators

• Texas State University: lead

Study Sites (1)

Cardiovascular Physiology Laboratory-Texas State University

San Marcos, Texas, 78666, United States

Location

Related Publications (1)

• Hunter SD, Bernardi L, McAllister MJ, John D, Rahimi M, Lopez MR. Device-guided slow breathing alters postprandial oxidative stress in young adult males: A randomized sham-controlled crossover trial. Nutr Metab Cardiovasc Dis. 2023 Jan;33(1):203-209. doi: 10.1016/j.numecd.2022.10.002. Epub 2022 Oct 10.

  PMID: 36344308 DERIVED

MeSH Terms

Conditions

Respiratory Aspiration

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: Participants will be blinded to the respiratory rates being practiced during each study visit. Breathing patterns will be completed in random order.
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Each participant will complete 2 different sessions in random order.

Study Record Dates

• First Submitted: March 29, 2021
• First Posted: April 28, 2021
• Study Start: December 1, 2020
• Primary Completion: September 30, 2021
• Study Completion: September 30, 2021
• Last Updated: November 9, 2021

Record last verified: 2021-11

Locations

US (1)