Micromegaly and Discrepancy Between Growth Hormone and IGF1 at the Diagnosis and Follow-up of Acromegalic Patients

NCT04860037 | Unknown

• 1 other identifier: RECHMPL21_0229
• Study Type: observational
• Target: 250
• Locations: 1 country
• Sites: 1

Brief Summary

The diagnosis and the follow-up of acromegalic patients are based on the mesurement of Growth hormone (GH) and IGF1 rates. However, the literature described some cases of patient for whom the investigators observed a discrepancy between GH and IGF1 rates. Since the acromegaly is a rare disease and this phenomenon concerns about 30% of these patients, there is a lack of investigations about consequences that this discordance may induces. In this study, the investigators aimed at assessing if patients with discordance between GH and IGF1 rates present a different risk of recurrence and complications related to acromegaly, from patients with concordant results.

Conditions

Acromegaly

Keywords

Endocrinology; Acromegaly; Discrepancy; Complications

Outcome Measures

Primary Outcomes (1)

• Occurrence of complications and/or recidivism related to acromegaly

  The investigators check in the patient file if there is complications or pathology recidivism detected at the last full check-up of the disease, assessed by blood-control and complementary exams

  day 1

Secondary Outcomes (1)

• Disease's specificity

  day 1

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult acromegalic patient followed up in the Occitanie region (independent endocrinologist ou working in hospital of Montpellier, Nimes or Béziers)

You may qualify if:

• Acromegaly followed up in one of the center (Montpellier, Nimes or Béziers hospital, independent endocrinologist) between 2010 and 2021
• Age over 18 years old
• Measurement of GH and IGF1 rates at the last visit control available

You may not qualify if:

• Lost to follow-up
• Status about complications related to acromegaly unknown

Sponsors & Collaborators

• University Hospital, Montpellier: lead

Study Sites (1)

Uhmontpellier

Montpellier, 34295, France

RECRUITING

MeSH Terms

Conditions

Acromegaly

Condition Hierarchy (Ancestors)

Bone Diseases, Endocrine; Bone Diseases; Musculoskeletal Diseases; Hyperpituitarism; Pituitary Diseases; Hypothalamic Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Endocrine System Diseases

Study Officials

• Isabelle RAINGEARD

  University Hospital, Montpellier

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Lucile MARTY, intern

CONTACT

06.71.31.76.37; lucile-marty@chu-montpellier.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 22, 2021
• First Posted: April 26, 2021
• Study Start: January 1, 2010
• Primary Completion: April 1, 2022
• Study Completion: December 1, 2022
• Last Updated: April 26, 2021

Record last verified: 2021-04

Locations

FR (1)