NCT04859634

Brief Summary

This prospective multicenter study will evaluate the efficacy of a real-time artificial intelligence system for detecting multiple ocular fundus lesions by ultra-widefield fundus imaging in real-world settings.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
2,000

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Nov 2020

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2020

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

April 15, 2021

Completed
11 days until next milestone

First Posted

Study publicly available on registry

April 26, 2021

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2022

Completed
11 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 25, 2022

Completed
Last Updated

April 26, 2021

Status Verified

April 1, 2021

Enrollment Period

1.3 years

First QC Date

April 15, 2021

Last Update Submit

April 23, 2021

Conditions

Keywords

Artificial IntelligenceDeep learningUltra-widefield Fundus ImagingOcular Fundus LesionsDiagnostic Screening Programs

Outcome Measures

Primary Outcomes (1)

  • Accuracy

    Performance of artificial intelligence system for detecting multiple ocular fundus lesions based on ultra-widefield fundus imaging.

    8 months

Secondary Outcomes (6)

  • Sensitivity

    8 months

  • Specificity

    8 months

  • Cohen's kappa coefficient

    8 months

  • False-positive rate

    8 months

  • False-negative rate

    8 months

  • +1 more secondary outcomes

Study Arms (7)

Zhongshan Ophthalmic Center

The participant only needs to take an ultra-widefield fundus image as usual.

Device: Taking an ultra-widefield fundus image

Shenzhen Ophthalmic Center

The participant only needs to take an ultra-widefield fundus image as usual.

Device: Taking an ultra-widefield fundus image

Beijin Tongren Hospital

The participant only needs to take an ultra-widefield fundus image as usual.

Device: Taking an ultra-widefield fundus image

Xudong Ophthalmic Center

The participant only needs to take an ultra-widefield fundus image as usual.

Device: Taking an ultra-widefield fundus image

IKang Physical Examination Center

The participant only needs to take an ultra-widefield fundus image as usual.

Device: Taking an ultra-widefield fundus image

Yangxi General Hospital People's Hospital

The participant only needs to take an ultra-widefield fundus image as usual.

Device: Taking an ultra-widefield fundus image

Guangdong Provincial People's Hospital

The participant only needs to take an ultra-widefield fundus image as usual.

Device: Taking an ultra-widefield fundus image

Interventions

The participant only needs to take an ultra-widefield fundus image as usual.

Beijin Tongren HospitalGuangdong Provincial People's HospitalIKang Physical Examination CenterShenzhen Ophthalmic CenterXudong Ophthalmic CenterYangxi General Hospital People's HospitalZhongshan Ophthalmic Center

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

All the participants who agree to take ultra-widefield fundus images.

You may qualify if:

  • All the participants who agree to take ultra-widefield fundus images.

You may not qualify if:

  • Patients who cannot cooperate with a photographer such as some paralytics, the patients with dementia and severe psychopaths.
  • Patients who do not agree to sign informed consent.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Zhongshan Ophthalmic Center, Sun Yat-sen University

Guangzhou, Guangdong, 510060, China

RECRUITING

Central Study Contacts

Haotian Lin, MD, PhD

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

April 15, 2021

First Posted

April 26, 2021

Study Start

November 1, 2020

Primary Completion

February 1, 2022

Study Completion

December 25, 2022

Last Updated

April 26, 2021

Record last verified: 2021-04

Locations