NCT04855539

Brief Summary

We will determine ventilator outcomes to Coronavirus Infectious Disease 2019 (COVID-19) using artificial Intelligence with inputs of chest radiographs and other evidence-based co-variates.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
300

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Mar 2020

Geographic Reach
1 country

3 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2020

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

April 19, 2021

Completed
3 days until next milestone

First Posted

Study publicly available on registry

April 22, 2021

Completed
9 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2021

Completed
7 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2021

Completed
Last Updated

September 16, 2021

Status Verified

September 1, 2021

Enrollment Period

1.2 years

First QC Date

April 19, 2021

Last Update Submit

September 14, 2021

Conditions

Covid19Pneumonia

Outcome Measures

Primary Outcomes (1)

  • Sensitivity and specificity of a convolutional neural network to predict survival outcome

    Defined by sensitivity, specificity, positive and negative predictive values

    1 month

Study Arms (2)

wave 1

wave 2

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

All adults with COVID-19 at secondary and tertiary centres

You may qualify if:

  • Admitted to intensive care unit (ITU) or equivalent COVID-19 polymerase chain reaction (PCR) positive

You may not qualify if:

  • No imaging prior to ITU admission

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Princess Royal University Hospital

Orpington, Kent, United Kingdom

RECRUITING

Guy's and St Thomas' Hospital

London, United Kingdom

RECRUITING

King's College Hospital

London, United Kingdom

RECRUITING

MeSH Terms

Conditions

COVID-19Pneumonia

Condition Hierarchy (Ancestors)

Pneumonia, ViralRespiratory Tract InfectionsInfectionsVirus DiseasesCoronavirus InfectionsCoronaviridae InfectionsNidovirales InfectionsRNA Virus InfectionsLung DiseasesRespiratory Tract Diseases

Central Study Contacts

Thomas C Booth, PhD

CONTACT

+44203299482thomas.booth@kcl.ac.uk

James Teo, PhD

CONTACT

+44203299482jamesteo@nhs.net

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 19, 2021

First Posted

April 22, 2021

Study Start

March 1, 2020

Primary Completion

May 1, 2021

Study Completion

December 1, 2021

Last Updated

September 16, 2021

Record last verified: 2021-09

Locations

GB(3)