Exercise Type That Faster Reduces Postprandial Glycemia.

NCT04846751 | Unknown DMC

• 1 other identifier: PID2020-116159RB-I00
• Study Type: interventional
• Target: 11
• Locations: 1 country
• Sites: 1

Brief Summary

It is well established that a bout of 50 min of continuous moderate intensity exercise, improves insulin sensitivity up to 48 hours after the bout. However, it is less well known, what is the exercise type more efficient to buffer the elevations in blood glucose elicited by carbohydrate ingestion. The purpose of this study is to elucidate if intervalic exercise is superior to continous on improving postprandial glycemic control.

Conditions

Glucose, High Blood; Exercise-Induced Hyperinsulinism

Outcome Measures

Primary Outcomes (2)

• Blood glucose concentration

  Incremental area under the curve during the 120 min of the oral glucose tolerance test

  16 weeks

• Blood insulin concentration

  Incremental area under the curve during the 120 min of the oral glucose tolerance test

  16 weeks

Secondary Outcomes (2)

• Carbohydrate oxidation

  16 weeks

• Turnover rate of endogenous and exogenous glucose

  16 weeks

Study Arms (2)

AEROBIC EXERCISE

ACTIVE COMPARATOR

50 min of aerobic exercise by pedaling a cycleergometer at 60% of VO2max

Behavioral: TYPE OF EXERCISE (OR REST)

PLACEBO REST

PLACEBO COMPARATOR

No exercise, resting during 50 min.

Behavioral: TYPE OF EXERCISE (OR REST)

Interventions

TYPE OF EXERCISE (OR REST) BEHAVIORAL

continous exercise in normal temperature, continous exercise in hot environment, intervallic exercise in normal temperature.

AEROBIC EXERCISE; PLACEBO REST

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participant must be capable and willing to provide consent, understand, instructions and protocols.
• Minimal fitness level to be able to complete 50 min of continous exercise at a moderate intensity.

You may not qualify if:

• Smokers
• Pregnancy
• Any non-controlled medical condition which could influence results or could be worsened by exercise

Sponsors & Collaborators

• University of Castilla-La Mancha: lead

Study Sites (1)

University of Castilla-La Mancha (Exercise Physiology Lab)

Toledo, 45071, Spain

Location

MeSH Terms

Conditions

Hyperinsulinemic hypoglycemia, familial, 7

Study Officials

• Ricardo Mora-Rodriguez, PhD

  University of Castilla-La Mancha

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of the Exercise Lab at Toledo

Model Details: Study composed of 4 trials, full-crossover, administered in a randomized order with the inclusion of a control trial.

Study Record Dates

• First Submitted: April 11, 2021
• First Posted: April 15, 2021
• Study Start: November 1, 2021
• Primary Completion: August 30, 2023
• Study Completion: September 10, 2024
• Last Updated: November 4, 2022

Record last verified: 2022-11

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)