The Relationship Between the Neural Drive and Intrinsic Positive End-expiratory Pressure

NCT04840628 | Completed DMC

• 1 other identifier: YLS2020(142)
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

To investigate the relation the nreural drive and intrinsic positive end-expiratory pressure(PEEPi) of the chronic obstructive pulmonary disease(COPD) patients with respiratory failure.In present study the PEEPi of COPD patients was increased by increasing the resistance of the respiratory system, the change of the neural drive was recorded.

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

neural respiratory drive; Intrinsic Positive End-expiratory Pressure; Chronic Obstructive Pulmonary Disease Patients

Outcome Measures

Primary Outcomes (1)

• neural respiratory drive assessed by the root mean square of diaphragm electromyogram (EMGdi) of the chronic obstructive pulmonary disease patients with respiratory failure

  neural respiratory drive assessed by the root mean square of diaphragm electromyogram (EMGdi) obtained from the a multi-pair esophageal electrode catheter

  1 hour

Study Arms (1)

neural respiratory drive

EXPERIMENTAL

neural respiratory drive assessed by EMGdi recorded from a multipair esophageal electrode

Other: Resistance of the respiratory system

Interventions

Resistance of the respiratory system OTHER

increase the resistance of the respiratory system of the chronic obstructive pulmonary disease patients

neural respiratory drive

Eligibility Criteria

• Age: 50 Years - 70 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• chronic obstructive pulmonary disease patients with respiratory failure

You may not qualify if:

• Heart failure
• cardiac dysrhythmia
• Loss of consciousness

Sponsors & Collaborators

• The First Affiliated Hospital of Guangzhou Medical University: lead

Study Sites (1)

1State Key Laboratory of Respiratory Disease, National clinical research center for respiratory disease, Guangzhou Institute of respiratory health. 2The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, 520120, China

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professor

Model Details: the chronic obstructive pulmonary disease patients with respiratory failure

Study Record Dates

• First Submitted: November 27, 2020
• First Posted: April 12, 2021
• Study Start: November 20, 2020
• Primary Completion: June 21, 2021
• Study Completion: July 3, 2021
• Last Updated: February 7, 2022

Record last verified: 2022-02

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)