Hemodynamic Effect of Prone Position in Non-intubated Patient With COVID 19

NCT04834947 | Unknown

• 1 other identifier: 69HCL21_0063
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Prone position in non-intubated patient has shown some respiratory physiological benefits. Prone positioning in patient intubated with ARDS has shown hemodynamic benefits. We aim to compare hemodynamic assessment before and after prone positioning in non-intubated patient with COVID 19 pneumonia. The study hypothesis is that prone positioning in non-intubated patient improve right ventricular preload, reduce afterload and increase Cardiac index compared to supine position.

Conditions

Covid19; Pneumonia, Viral

Keywords

COVID 19; prone position; hemodynamic effect; spontaneous ventilation

Outcome Measures

Primary Outcomes (1)

• Hemodynamic effect

  Cardiac index

  Cardiac index will be recorded before, just after prone position and after return to supine position.

Study Arms (1)

Prone position in non-intubated COVID19 , before and after.

Patients with non-intubated COVID19 pneumoniae for whom the clinician has decided to try prone positioning to increase the PaO2 in a context of hypoxemia with O2 requirement.

Procedure: prone position

Interventions

prone position PROCEDURE

Choice of prone positioning a patient is at the discretion of the anesthesia physician.

Prone position in non-intubated COVID19 , before and after.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients scheduled for cadiac surgery wih cardiopulmonary bypass

You may qualify if:

• Adult patient
• COVID 19 pneumonias with Hypoxemia
• for whom prone positioning has been decided by the attending physician.

You may not qualify if:

• Mechanical ventilation
• ECLS

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Service d'Anesthésie-Réanimation, Hôpital Louis Pradel,

Bron, France

Location

MeSH Terms

Conditions

COVID-19; Pneumonia, Viral

Interventions

Prone Position

Condition Hierarchy (Ancestors)

Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Posture; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

Matthias JACQUET LAGREZE, MD

CONTACT

0033472318933; matthias.jacquet-lagrèze@chu-lyon.fr

Jean Luc FELLAHI, MD

CONTACT

0033472318933; jean-luc.fellahi@chu-lyon.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 6, 2021
• First Posted: April 8, 2021
• Study Start: April 15, 2021
• Primary Completion: December 15, 2021
• Study Completion: December 15, 2021
• Last Updated: April 8, 2021

Record last verified: 2021-03

Locations

FR (1)