Firm Observational Clinical Unicenter Study on Guillain Barré Syndrome

NCT04829526 | Recruiting

• 1 other identifier: 2021-00402; ko21Sutter
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this retrospective observational single-center cohort study is to gain a deeper understanding regarding the frequency, the clinical and electrophysiologic characteristics (e.g., the diagnostic work up), complications, treatment regimes, and their associations with specific courses of disease and outcomes in adult patients with the suspected or proven diagnosis of GBS.

Conditions

Guillain-Barre Syndrome (GBS)

Outcome Measures

Primary Outcomes (6)

• frequency of GBS

  frequency of GBS of all consecutive adult patients with the suspected initial diagnosis of GBS (admitted to the University Hospital Basel)

  one time retrospective assessment at baseline

• clinical characteristics of GBS

  clinical characteristics of GBS of all consecutive adult patients with the suspected initial diagnosis of GBS (admitted to the University Hospital Basel)

  one time retrospective assessment at baseline

• electrophysiologic characteristics of GBS

  electrophysiologic characteristics of GBS of all consecutive adult patients with the suspected initial diagnosis of GBS (admitted to the University Hospital Basel)

  one time retrospective assessment at baseline

• complications of GBS

  complications of GBS of all consecutive adult patients with the suspected initial diagnosis of GBS (admitted to the University Hospital Basel)

  one time retrospective assessment at baseline

• treatment regimes of GBS

  treatment regimes of GBS of all consecutive adult patients with the suspected initial diagnosis of GBS (admitted to the University Hospital Basel)

  one time retrospective assessment at baseline

• outcomes of GBS

  treatment regimes of GBS of all consecutive adult patients with the suspected initial diagnosis of GBS (admitted to the University Hospital Basel)

  one time retrospective assessment at baseline

Interventions

data collection OTHER

Retrospective extraction of demographic, clinical, laboratory, and electrophysiological data from the digital medical records

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients with the suspected and with the final proven diagnosis of GBS in the years 2005-2021

You may qualify if:

• suspected diagnosis of GBS, who have been treated at the University Hospital of Basel from 01.01.2005-28.02.2021

You may not qualify if:

• Patients with documented refusal of the general consent.

Sponsors & Collaborators

• University Hospital, Basel, Switzerland: lead

Study Sites (1)

Clinic for Intensive Care Medicine; University Hospital Basel

Basel, 4031, Switzerland

RECRUITING

MeSH Terms

Conditions

Guillain-Barre Syndrome

Interventions

Data Collection

Condition Hierarchy (Ancestors)

Polyradiculoneuropathy; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Polyneuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Autoimmune Diseases; Immune System Diseases; Post-Infectious Disorders; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Raoul Sutter, Prof. Dr. med.

  Clinic for Intensive Care Medicine, University Hospital Basel

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Raoul Sutter, Prof. Dr. med.

CONTACT

+41 61 32 87 928; raoul.sutter@usb.ch

Lisa Hert, Dr. med.

CONTACT

lisa.hert@usb.ch

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 29, 2021
• First Posted: April 2, 2021
• Study Start: March 1, 2021
• Primary Completion (Estimated): July 1, 2026
• Study Completion (Estimated): July 1, 2026
• Last Updated: December 17, 2024

Record last verified: 2024-12

Locations

CH (1)