Evaluation of a Screening Strategy for Sarcopenia: a Monocentric Prospective Cohort Study (STRAS)

NCT04827758 | Terminated

• 2 other identifiers: GHRMSA 1094IDRCB 2020-A02364-35
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

The main objective of this study is to determine the prevalence of sarcopenia in patients hospitalized in the follow-up care and rehabilitation units of the geriatrics department of the Mulhouse French hospital.

Conditions

Sarcopenia

Keywords

sarcopenia; muscle strength; muscle mass; older people

Outcome Measures

Primary Outcomes (1)

• Number of patients with sarcopenia

  The diagnosis of sarcopenia will be established according to the 2018 criteria of the European Working Group On Sarcopenia in Older People (EWGSOP2) based on the evaluation of muscle strength and muscle mass. Sarcopenia will be defined by an abnormal value measured by a grip test and confirmed by an abnormal value of the ASM/size2 ratio measured by impedancemetry.

  Enrollment

Secondary Outcomes (8)

• Sensitivity, specificity, positive and negative predictive value of the SARC-F questionnaire

  Enrollment

• Characteristics of sarcopenic patients hospitalized in each follow-up care and rehabilitation unit (i.e. day hospital, full hospitalization)

  Enrollment

• Muscle strength

  Hospital discharge assessed up to 3 months

• Muscle mass

  Hospital discharge assessed up to 3 months

• 4-meter walking speed test

  Hospital discharge assessed up to 3 months

Study Arms (1)

Patients hospitalized in the follow-up care and rehabilitation units

OTHER

Procedure: Screening and diagnostic tests for sarcopenia

Interventions

Screening and diagnostic tests for sarcopenia PROCEDURE

All of the following tests and questionnaires will be performed : * SARC-F questionnaire, * measurement of muscle strengh by a grip test, * measurement of muscle mass by impedancemetry (ASM/size2), * 4-meter walking speed test, * Timed-Up and Go (TUG) test, * ADL (Activities of Daily Living) and IADL (Instrumental Activities of Daily Living) questionnaires.

Patients hospitalized in the follow-up care and rehabilitation units

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patient 60 years of age or older
• Patients hospitalized in the follow-up care and rehabilitation units (i.e. day hospital, full hospitalization) of the geriatrics department of the Mulhouse French hospital
• Patient who gave consent to participate in the study
• Affiliated or beneficiary of a social security scheme

You may not qualify if:

• Patient admitted for palliative care
• Bedridden patient
• Patient with major neurocognitive disorders preventing impedancemetry or grip test from being performed, or any other medical condition preventing impedancemtery or grip test from being performed
• Patient under legal protection
• Patient with an unstable psychiatric disorder
• Patient under guardianship or curatorship
• Patient already included in the study during a previous hospitalization
• \- For patients hospitalized in the conventional follow-up care and rehabilitation unit (i.e. full hospitalization), impedancemtry or grip test not performed within 7 days of admission.
• Patients excluded secondarily will not be replaced.

Sponsors & Collaborators

• Groupe Hospitalier de la Region de Mulhouse et Sud Alsace: lead

Study Sites (1)

GHRMSA - Hôpital Emile MULLER

Mulhouse, 68100, France

Location

MeSH Terms

Conditions

Sarcopenia

Interventions

Mass Screening

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Diagnostic Techniques and Procedures; Diagnosis; Health Surveys; Surveys and Questionnaires; Data Collection; Epidemiologic Methods; Investigative Techniques; Diagnostic Services; Preventive Health Services; Health Services; Health Care Facilities Workforce and Services; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health; Public Health Practice

Study Officials

• Xavier SIRLIN, MD

  Groupe Hospitalier de la Region de Mulhouse et Sud Alsace

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 24, 2021
• First Posted: April 1, 2021
• Study Start: April 22, 2021
• Primary Completion: September 23, 2022
• Study Completion: September 23, 2022
• Last Updated: October 28, 2022

Record last verified: 2022-10

Locations

FR (1)