Drug Allergy Labels After Drug Allergy Investigation

NCT04827602 | Completed

• 1 other identifier: GEH-R-20068776
• Study Type: observational
• Target: 849
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to investigate the degree of match between the drug allergy label in the hospital's electronic health record and primary care's electronic health record among patients who previously have been drug allergy tested.

Conditions

Drug Hypersensitivity

Keywords

drug allergy; drug allergy labels; penicillin allergy labels

Outcome Measures

Primary Outcomes (1)

• Degree of matching drug allergy testing and drug allergy labels

  Degree of match between allergy testing outcomes and registered drug allergy labels in primary care and hospital electronic health records

  Baseline

Secondary Outcomes (1)

• Degree of match between registered drug allergy labels

  Baseline

Other Outcomes (1)

• Analysis of predictors for failure to update drug allergy labels

  Baseline

Study Arms (1)

Allergy tested group

Patients who have completed penicillin allergy testing

Other: Drug allergy label status in electronic health records

Interventions

Drug allergy label status in electronic health records OTHER

Registered drug allergy labels in primary care and hospital electronic medical charts

Allergy tested group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population is made up of patients who completed penicillin allergy testing in 2017 to 2019 at the Allergy Clinic, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark. The study population is estimated to 900 participants from both the Capital Region and Region Zealand.

You may qualify if:

• Penicillin allergy tested at the Allergy Clinic, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark in 2017-2019

Sponsors & Collaborators

• University Hospital, Gentofte, Copenhagen: lead
• Research Unit Of General Practice, Copenhagen: collaborator

Study Sites (1)

Allergy Clinic, Department of Dermato-Allergology, Copenhagen University Hospital

Copenhagen, 2900, Denmark

Location

Related Publications (3)

• Lachover-Roth I, Sharon S, Rosman Y, Meir-Shafrir K, Confino-Cohen R. Long-Term Follow-Up After Penicillin Allergy Delabeling in Ambulatory Patients. J Allergy Clin Immunol Pract. 2019 Jan;7(1):231-235.e1. doi: 10.1016/j.jaip.2018.04.042. Epub 2018 May 22.

  PMID: 29800754 RESULT

• Vyles D, Chiu A, Routes J, Castells M, Phillips EJ, Kibicho J, Brousseau DC. Antibiotic Use After Removal of Penicillin Allergy Label. Pediatrics. 2018 May;141(5):e20173466. doi: 10.1542/peds.2017-3466.

  PMID: 29678929 RESULT

• Sacco KA, Bates A, Brigham TJ, Imam JS, Burton MC. Clinical outcomes following inpatient penicillin allergy testing: A systematic review and meta-analysis. Allergy. 2017 Sep;72(9):1288-1296. doi: 10.1111/all.13168. Epub 2017 Apr 26.

  PMID: 28370003 RESULT

MeSH Terms

Conditions

Drug Hypersensitivity

Interventions

Electronic Health Records

Condition Hierarchy (Ancestors)

Drug-Related Side Effects and Adverse Reactions; Chemically-Induced Disorders

Intervention Hierarchy (Ancestors)

Medical Records Systems, Computerized; Medical Records; Records; Data Collection; Epidemiologic Methods; Investigative Techniques; Organization and Administration; Health Services Administration; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Lene H. Garvey

  Allergy Clinic, Copenhagen University Hospital, Copenhagen

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Ph.D student

Study Record Dates

• First Submitted: March 30, 2021
• First Posted: April 1, 2021
• Study Start: April 15, 2021
• Primary Completion: July 15, 2021
• Study Completion: July 15, 2021
• Last Updated: May 26, 2022

Record last verified: 2022-05

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)