Malignant Testicular Tumors in Children: A Single Institution's 12-year Experience

NCT04826952 | Completed

• 1 other identifier: 20201912B0
• Study Type: observational
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

Background and Objectives. Testicular neoplasms are not commonly found in children, a formidable threat if treated inappropriately. However, there is no consensus concerning their management. The study aimed to present a holistic picture of the integrated treatment of malignant testicular tumors based on our 12 years' experience. Patients and Methods. This institutional-based retrospective cohort study evaluated clinical presentation, histopathologic diagnosis, treatment, and outcome in 42 boys with malignant neoplasm of testis treated between 2006 and 2019.

Conditions

Overall Survival Rates

Keywords

Testicular tumor, children, histology, orchiectomy, inguinal approach

Outcome Measures

Primary Outcomes (1)

• The 1- and 5-year overall survival rates

  Malignant testicular tumors in children:

  between May 2006 and November 2019

Interventions

Orchiectomy PROCEDURE

Childhood testicular tumors deserve special diagnostic attention from the therapeutic point of view. A testicular tumor should be considered malignant until proven otherwise. In cases with suspicion of testicular tumors, the inguinal approach is preferred to the scrotal approach for scrotal violation.

Eligibility Criteria

• Age: 0 Years - 19 Years
• Gender Eligibility Details: We retrospectively investigated the outcomes of 42 boys aged 0-19 years presenting with testicular masses.
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

The evaluation included age at presentation, medical history, clinical characteristics, diagnostic procedures, treatment methods, histopathologic findings, and outcomes for every patient. All patients received the examinations of color Doppler ultrasonography of the testis and the abdomen, plain x-ray of the thorax, and serum α-fetoprotein (AFP) levels before operations. The AFP measurement is usually very high in newborns and does not decrease to normal adult levels until 8 months. Thus, the AFP levels of infants were evaluated according to reference ranges.

You may qualify if:

• aged 0-19 years presenting with malignant testicular masses

You may not qualify if:

• patients with incomplete records

Sponsors & Collaborators

• Chang Gung Memorial Hospital: lead

Study Sites (1)

Chang Gung Memorial Hospital

Taoyuan District, Other, 33315, Taiwan

Location

MeSH Terms

Conditions

Testicular Neoplasms

Interventions

Orchiectomy

Condition Hierarchy (Ancestors)

Endocrine Gland Neoplasms; Neoplasms by Site; Neoplasms; Genital Neoplasms, Male; Urogenital Neoplasms; Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Male Urogenital Diseases; Endocrine System Diseases; Testicular Diseases; Gonadal Disorders

Intervention Hierarchy (Ancestors)

Castration; Endocrine Surgical Procedures; Surgical Procedures, Operative; Urogenital Surgical Procedures; Urologic Surgical Procedures, Male; Urologic Surgical Procedures

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 28, 2021
• First Posted: April 1, 2021
• Study Start: December 1, 2020
• Primary Completion: February 28, 2021
• Study Completion: February 28, 2021
• Last Updated: April 1, 2021

Record last verified: 2021-03

Locations

TW (1)