Study of the Role of Hemostasis in Perioperative Anaphylaxis
HEMOCANOPE
1 other identifier
observational
30
0 countries
N/A
Brief Summary
Anaphylaxis is a severe and life-threatening complication during the perioperative period. Perioperative anaphylaxis is still associated with a significant mortality despite quick and efficient management using epinephrine, the mainstay of acute treatment. Experimental data and few case reports are suggesting that hemostasis, and more precisely platelets, could play a role in anaphylaxis. Our main hypothesis is that activation of the hemostatic system contributes to the severity of the reaction
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Apr 2021
Typical duration for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 21, 2021
CompletedFirst Posted
Study publicly available on registry
April 1, 2021
CompletedStudy Start
First participant enrolled
April 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
February 9, 2024
CompletedApril 1, 2021
March 1, 2021
Same day
January 21, 2021
March 30, 2021
Conditions
Outcome Measures
Primary Outcomes (4)
Platelet activation
Measurement of: Plasmatic serotonin level, Plasmatic PF-4 level, P-selectin expression (MFI, %), Platelet count
As soon as possible after onset of anaphylaxis
Platelet activation
Measurement of: Plasmatic serotonin level, Plasmatic PF-4 level, P-selectin expression (MFI, %), Platelet count
1-2 hours after the onset of anaphylaxis
Platelet activation
Measurement of: Plasmatic serotonin level, Plasmatic PF-4 level, P-selectin expression (MFI, %), Platelet count
24 hours after the onset of anaphylaxis
Platelet activation
Measurement of: Plasmatic serotonin level, Plasmatic PF-4 level, P-selectin expression (MFI, %), Platelet count
During the allergic workup (4-6 weeks after)
Eligibility Criteria
The study will focus on any adult patient with a suspected diagnosis of perioperative anaphylactic shock
You may qualify if:
- Patient, male or female, adult
- In the perioperative period
- In whom the diagnosis of anaphylactic shock is suggested
- Patient is giving his consent to participate in the study
You may not qualify if:
- Subject under legal protection
- Subject under guardianship or guardianship
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Biospecimen
* Whole blood * Plasma
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 21, 2021
First Posted
April 1, 2021
Study Start
April 1, 2021
Primary Completion
April 1, 2021
Study Completion
February 9, 2024
Last Updated
April 1, 2021
Record last verified: 2021-03