Exercise Echocardiography on LV Mechanics in Patients With CAD: a Speckle-tracking Echocardiography

NCT04824001 | Unknown

• 1 other identifier: CMUH108-REC2-180
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

Recovering blood flow to a coronary stenosis may improve left ventricular (LV) function in patients with coronary artery disease (CAD). However, the reported data about evaluation of LV function post-percutaneous coronary intervention (PCI) in CAD was limited. The aim of this study was to compare the LV function measured by 3 min low dose exercise stress echocardiography (ESE) combined 2D speckle tracking echocardiography (STE) in patients with CAD underwent PCI, and to identify factors affecting the change of LV function. Patients with CAD who underwent acute PCI were enrolled.

Conditions

Cardiovascular Diseases; STEMI; NSTEMI

Keywords

stress echocardiography; speckle tracking

Outcome Measures

Primary Outcomes (1)

• The alterations of LV mechanics responses to a 3-min low dose exercise stress echocardiography following time.

  The STE was performed at rest, during exercise and recovery to compare the changes of LV machines following discharge. The standardized exercise test was conducted by 50-W semirecumbent cycling (Cardiac Stress Table w/Angio) for 3 min. Stress echocardiograph images were acquired at the third minute of cycling to ensure that subjects had reached a steady-state HR.

  detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.

Secondary Outcomes (10)

• Cardiopulmonary fitness

  detected at the day 30, 60, and 180 after discharge.

• The brain-type natriuretic peptide (BNP) levels

  detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge.

• The high-sensitivity CRP (hsCRP) levels

  detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge.

• The creatine kinase (CK) levels

  detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge.

• The creatine kinase-MB (CK-MB) levels

  detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge.

Study Arms (2)

STEMI

ST-segment elevation myocardial infarction (STEMI) is defined by symptoms of myocardial ischemia accompanied by a persistent elevation of the ST segment on the electrocardiogram (ECG) and the subsequent release of biomarkers of myocardial necrosis.

Other: exercise stress echocardiography

NSTEMI

If there is elevation of the blood markers suggesting heart damage, but no ST elevation seen on the EKG tracing, this is known as a non ST-elevation myocardial infarction (NSTEMI).

Other: exercise stress echocardiography

Interventions

exercise stress echocardiography OTHER

Stress echocardiography test. The standardized exercise test was conducted by 50-W semi-recumbent cycling for 3 min. Stress echocardiograph images were acquired at the third minute of cycling to ensure that subjects had reached a steady-state HR.

NSTEMI; STEMI

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

acute myocardial infarction diagnosed by a physician and undergoing percutaneous coronary intervention

You may qualify if:

• acute myocardial infarction diagnosed by a physician
• undergoing percutaneous coronary intervention
• Exercise testing and stress echocardiography are performed with the approval of the physician.

You may not qualify if:

• Severe cardiac valve disease
• Left bundle branch block
• Uncontrolled diabetes or hypertension
• Orthopedics or other conditions that hinder from exercise
• Uncontrolled sinus tachycardia (greater than 120 beats per minute)

Sponsors & Collaborators

• China Medical University Hospital: lead

Study Sites (1)

Asia University Hospital

Wufeng District, Taichung, 413, Taiwan

RECRUITING

Related Publications (4)

• Anand IS, Kuskowski MA, Rector TS, Florea VG, Glazer RD, Hester A, Chiang YT, Aknay N, Maggioni AP, Opasich C, Latini R, Cohn JN. Anemia and change in hemoglobin over time related to mortality and morbidity in patients with chronic heart failure: results from Val-HeFT. Circulation. 2005 Aug 23;112(8):1121-7. doi: 10.1161/CIRCULATIONAHA.104.512988. Epub 2005 Aug 15.

  PMID: 16103233 BACKGROUND

• Sikora-Frac M, Zaborska B, Maciejewski P, Budaj A, Bednarz B. Improvement of left ventricular function after percutaneous coronary intervention in patients with stable coronary artery disease and preserved ejection fraction: Impact of diabetes mellitus. Cardiol J. 2021;28(6):923-931. doi: 10.5603/CJ.a2019.0066. Epub 2019 Jul 1.

  PMID: 31257568 BACKGROUND

• Li H, Liu C, Zhang G, Wang C, Sun P, Du G, Tian J. The early alteration of left ventricular strain and dys-synchrony index in breast cancer patients undergoing anthracycline therapy using layer-specific strain analysis. Echocardiography. 2019 Sep;36(9):1675-1681. doi: 10.1111/echo.14460. Epub 2019 Aug 27.

  PMID: 31454106 BACKGROUND

• Huang YC, Tsai HH, Fu TC, Hsu CC, Wang JS. High-Intensity Interval Training Improves Left Ventricular Contractile Function. Med Sci Sports Exerc. 2019 Jul;51(7):1420-1428. doi: 10.1249/MSS.0000000000001931.

  PMID: 30829901 BACKGROUND

MeSH Terms

Conditions

Cardiovascular Diseases; ST Elevation Myocardial Infarction; Non-ST Elevated Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial Infarction; Myocardial Ischemia; Heart Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• LI-Wei Chou, PhD

  China Medical University Hospital/Asia University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

LI-Wei Chou, PhD

CONTACT

+886-4-22052121; chouliwe@mail.cmuh.org.tw

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Minister of Rehabilitation

Study Record Dates

• First Submitted: February 26, 2021
• First Posted: April 1, 2021
• Study Start: January 13, 2021
• Primary Completion: July 31, 2022
• Study Completion: July 31, 2022
• Last Updated: April 1, 2021

Record last verified: 2021-03

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)