Effects of Adapated Physical Activity Program on Kynurenin Metabolism During Refeeding in Anorexia Nervosa : APANOR Study

NCT04817436 | Terminated

• 1 other identifier: 2017/0383/HP
• Study Type: interventional
• Target: 9
• Locations: 1 country
• Sites: 1

Brief Summary

Physical hyperactivity is often associated to anorexia nervosa (AN). Data suggest common central pathways between hyperactivity and anorexia. Maintaining adapted physical activity (APA) during refeeding in AN is controversial. Many studies suggest beneficits of APA in AN on body composition (increase fat free mass and better distribution of fat mass), mood regulation, bone metabolism. We recently reported benefits of maintaining physical activity during refeeding in a mice model of anorexia (activity-based anorexia model). These benefits involved the tryptophan-kynurenin pathway. Thus, we aim in the APANOR study to assess effects of APA during refeeding in AN on kynurenin metabolism.

Conditions

Anorexia Nervosa

Outcome Measures

Primary Outcomes (1)

• To evaluate the effects of adapated physical activity (APA) program on kynurenin metabolism

  Variation of plasmatic kynurenin acid between V1 and V2 in patients undergoing APA during refeeding versus other patients (control group without APA)

  3 months

Secondary Outcomes (5)

• To evaluate the effects of adapated physical activity program on anthropometric data.

  3 months

• To evaluate the involving of gut microbiota composition and diversity

  3 months

• To evaluate the effects of adapated physical activity program on quality of life

  3 months

• To evaluate the involving of auto-antibodies against neuropeptides involved in food intake regulation

  3 months

• To evaluate the effects of adapated physical activity program on Body composition (fat mass, fat free mass)

  3 months

Study Arms (2)

Without adapted physical activity program (APA)

ACTIVE COMPARATOR

Other: physical activity program (APA)

With adapted physical activity program (APA)

EXPERIMENTAL

Other: physical activity program (APA)

Interventions

physical activity program (APA) OTHER

adapted physical activity program (APA)

With adapted physical activity program (APA); Without adapted physical activity program (APA)

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Female
• Patient \> 18 years
• Follow-up in the department of clinical Nutrition of Rouen
• BMI ≥15,0 and \<18,5 kg/m²
• Diagnosis of anorexia nervosa according to DSM-V classification

You may not qualify if:

• Physical activity contraindications : hemodynamic disorder, uncontrolled cardiovascular disease, intracranial hypertension
• Patients with poor understanding of spoken or written French
• Person deprived of their liberty by an administrative or judicial decision or person subject to a legal measure for the protection of adults
• Person subject to a safeguard of justice, guardianship or curatorship.
• Pregnant or breastfeeding woman

Sponsors & Collaborators

• University Hospital, Rouen: lead

Study Sites (1)

Chu Rouen

Rouen, 76031, France

Location

MeSH Terms

Conditions

Anorexia Nervosa

Condition Hierarchy (Ancestors)

Feeding and Eating Disorders; Mental Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 25, 2020
• First Posted: March 26, 2021
• Study Start: September 8, 2021
• Primary Completion: September 8, 2025
• Study Completion: September 8, 2025
• Last Updated: May 6, 2026

Record last verified: 2026-04

Locations

FR (1)