NCT04815161

Brief Summary

The ASTORIA study is a prospective cohort single-armed multicenter observational study that aims to assess adherence to rivaroxaban using a high technological electronical pillbox connected to a phone application in a group of atrial fibrillation patients with indication of long term anticoagulation treatment in routine clinical practice.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
200

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jun 2022

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 10, 2021

Completed
14 days until next milestone

First Posted

Study publicly available on registry

March 24, 2021

Completed
1.2 years until next milestone

Study Start

First participant enrolled

June 1, 2022

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2023

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2023

Completed
Last Updated

May 24, 2022

Status Verified

May 1, 2022

Enrollment Period

1 year

First QC Date

March 10, 2021

Last Update Submit

May 23, 2022

Conditions

Outcome Measures

Primary Outcomes (1)

  • Rate of adherence

    The rate of adherence to rivaroxaban in a group of atrial fibrillation patients using the Pilloxa box will be assessed.

    2 years

Secondary Outcomes (3)

  • Persistence rate

    2 years

  • Rates of risk factors

    2 years

  • Rates of different patient experiences

    2 years

Study Arms (1)

Pilloxa pillbox

OTHER

Patients receiving the Pilloxa pillbox for drug administration

Behavioral: Adherence

Interventions

AdherenceBEHAVIORAL

Adherence to medication using an electronic pillbox

Pilloxa pillbox

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Female or male patient with age \> 18 years
  • Patients with atrial fibrillation
  • Patients initiated, continued on or switched to rivaroxaban for the indication atrial fibrillation with intended lifelong treatment (CHA2 DS2-VASc score ≥ 1).
  • The patient must agree to the use of the electronic medication adherence monitoring device, the so-called Pilloxa box and need to have a sufficient understanding of the app and functionality in conjunction with the use of the Pilloxa box.
  • Signed informed consent
  • No participation in an investigational program with interventions outside of routine clinical practice
  • No contra-indications according to the local marketing authorization

You may not qualify if:

  • Participation in an investigational program with interventions outside of routine clinical practice
  • Contra-indications according to the local marketing authorization

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Patient ComplianceAtrial Fibrillation

Condition Hierarchy (Ancestors)

Patient Acceptance of Health CareTreatment Adherence and ComplianceHealth BehaviorBehaviorArrhythmias, CardiacHeart DiseasesCardiovascular DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Dan Atar, MD, PhD

    Univerity of Oslo, Oslo University Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Dan Atar, MD, PhD

CONTACT

Marita Knudsen Pope, MD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
OTHER
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

March 10, 2021

First Posted

March 24, 2021

Study Start

June 1, 2022

Primary Completion

June 1, 2023

Study Completion

August 1, 2023

Last Updated

May 24, 2022

Record last verified: 2022-05

Data Sharing

IPD Sharing
Will not share

We do not plan to share IPD.