Cognition, Sleep, Neurophysiology of Suicidal Depressed Patients

NCT04813835 | Completed

• 1 other identifier: cognition Suicidal Depression
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

evaluation whether suicidal major depressive disorder patients show a specific pattern of cognitive, sleep and neurophysiologic impairment as compared to non- suicidal major depressive disorder patient, and studying the correlation between the cognitive impairment, the sleep disturbance and the neurophysiologic impairment and suicidal behaviour Studying the cognitive profile in suicidal patient including studying, Comprehension, Attention, language production, reasoning, problem solving and decision making

Conditions

Suicidal Depression

Keywords

cognition; sleep; neurophysiology; suicidal depression

Outcome Measures

Primary Outcomes (3)

• Cognition among Suicidal Depressed patients

  1. to determine the cognitive impairment among depressed suicidal patient compared to not depressed persons and to depressed non suicidal patients by 1-Mini-mental state examination: It as a basic tool used to assess the cognitive function; it includes tests of orientation, attention, memory, language and visual-spatial skills 2. Montreal cognitive assessment scale: The test is a one-page 30-point test administered in approximately 10 minutes. Each participant had the test individually. it was used to assess several domains of cognition such as the short term memory recall task (5 points) involves two learning trials of five nouns and delayed recall after approximately 5minutes

  one day

• sleep among Suicidal Depressed patients

  Epworth sleepiness scale: The Epworth Sleepiness Scale (ESS) is a scale intended to measure daytime sleepiness that is measured by use of a very short questionnaire. This can be helpful in screening of sleep disorders.

  10 minutes

• neurophysiological marker among Suicidal Depressed patients

  Standard Electroencephalogram "EEG": Conventional EEG will be done using the 8 channels Nihon Kohden machine '4217' employing scalp electrodes placed according to the international 10-20 system with bipolar and referential montages . for evaluation of power in alpha band

  1 hour

Study Arms (3)

suicidal depressed patients

psychiatric history suicidal scale mental state examination screening for sleep disturbance electroencephalography

depressed patients

psychiatric history suicidal scale mental state examination screening for sleep disturbance electroencephalography

control

psychiatric history suicidal scale mental state examination screening for sleep disturbance electroencephalography

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

study population are grouped to 3 groups 1. suicidal depressed patient 2. depressed patients 3. control or normal people

You may qualify if:

• Suicidal attempters, suicidal ideators, non-suicidal depressed were all diagnosed with major depression, or Bipolar disorder (BD) (depressive phase) by statistical manual of mental disorders. Patients meeting DSM-5 criteria. (APA-2013)
• all participant provided written informed consent
• \. Match with the subjects in age group "above 18 years old" 2.no history of suicide attempt or ideation 3. no history of psychiatric disorder

You may not qualify if:

• other psychiatric disorders
• electroconvulsive therapy in the Previous six months
• Neurologic disorders including stroke, epilepsy, brain injury and sensory disorders that precluded participating in cognitive assessment.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut University

Asyut, Egypt

Location

Related Publications (2)

• W. S. F. Pickering; Geoffrey Walford (2000). Durkheim's Suicide: a century of research and debate. Psychology Press. p. 25.

  BACKGROUND

• Hassan, Wageeh .A.N., Noamany, M.M.(2020). . A clinical study of suicide in patients admitted in psychiatry unit in Assiut University. Middle East Current Psychiatry 27, 26

  BACKGROUND

Study Officials

• Mohamed F. Abd-ElAal, Professor

  Assiut University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 26, 2021
• First Posted: March 24, 2021
• Study Start: December 1, 2021
• Primary Completion: December 1, 2022
• Study Completion: January 1, 2023
• Last Updated: February 5, 2024

Record last verified: 2024-02

Locations

EG (1)