NCT04813081

Brief Summary

The purpose of this study is to evaluate the quality of life of patients who underwent FGG surgery around the natural tooth and as a second surgery after the implant operation, in comparison with general oral health assesment index(GOHAI).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
32

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started May 2017

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2017

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 31, 2019

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

March 4, 2019

Completed
2 years until next milestone

First Submitted

Initial submission to the registry

March 18, 2021

Completed
6 days until next milestone

First Posted

Study publicly available on registry

March 24, 2021

Completed
Last Updated

March 24, 2021

Status Verified

March 1, 2021

Enrollment Period

1.8 years

First QC Date

March 18, 2021

Last Update Submit

March 23, 2021

Conditions

Keywords

quality of lifegraft

Outcome Measures

Primary Outcomes (1)

  • General Oral Health Assesment Index (GOHAI) scores- intragroup comparisons change between from baseline to other follow-up times and intergroup comparisons all follow-up times

    The questions that contains 12 items and that give subcategorized about functional limitations, pain and discomfort, psychological impacts, and behavioral impact.

    Baseline, postoperative 1., 2., 3., 4., 5., 6. and 7. days and first month.

Secondary Outcomes (1)

  • Age

    baseline

Other Outcomes (8)

  • Gender

    baseline

  • Keratinized gingival width (KGW)

    baseline, first month

  • Graft volume (GV)

    during surgery

  • +5 more other outcomes

Study Arms (2)

Free gingival graft around dental implant patients

ACTIVE COMPARATOR

Test Group (TG) consists of patients have free gingival graft around dental implant patients

Procedure: Free Gingival Graft

Free gingival graft around the teeth

ACTIVE COMPARATOR

Control Group (CG) consists of patients have free gingival graft around the teeth.

Procedure: Free Gingival Graft

Interventions

In the recipient area, a half-thickness flap with two vertical incision widths was removed with a horizontal incision with 15C blades from the mucogingival junction. The recipient site was determined such that one or two teeth or one tooth extends into the mesial and distal regions of the tooth. Muscle attachments were dissected and FGG was placed on recipient bed and non-resorbable monofilament sutures were used for fixing the four corners of the graft.

Free gingival graft around dental implant patientsFree gingival graft around the teeth

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Non-smoking
  • Teeth and implants with keratinized gingiva width \<1 mm
  • A healthy periodontal and peri-implant condition
  • Patients who didn't have ever experience periodontal surgery had first oral surgery experience with dental FGG operation for the first time
  • Patients who underwent implant surgery for the first oral surgery experience
  • Maximum two teeth/implants on recipient area

You may not qualify if:

  • Patients receiving any medication to disrupt wound healing
  • Lactation or pregnancy
  • Caries or defects on the tooth root surface
  • Periapical lesion in the recipient area active periodontal disease
  • Patients who have previously had periodontal or oral surgery experiences

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Beykent University Faculty of Dentistry

Istanbul, 34500, Turkey (Türkiye)

Location

Related Publications (5)

  • Zucchelli G, Tavelli L, McGuire MK, Rasperini G, Feinberg SE, Wang HL, Giannobile WV. Autogenous soft tissue grafting for periodontal and peri-implant plastic surgical reconstruction. J Periodontol. 2020 Jan;91(1):9-16. doi: 10.1002/JPER.19-0350. Epub 2019 Oct 6.

  • Berglundh T, Armitage G, Araujo MG, Avila-Ortiz G, Blanco J, Camargo PM, Chen S, Cochran D, Derks J, Figuero E, Hammerle CHF, Heitz-Mayfield LJA, Huynh-Ba G, Iacono V, Koo KT, Lambert F, McCauley L, Quirynen M, Renvert S, Salvi GE, Schwarz F, Tarnow D, Tomasi C, Wang HL, Zitzmann N. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol. 2018 Jun;45 Suppl 20:S286-S291. doi: 10.1111/jcpe.12957.

  • McGuire MK, Scheyer ET, Gwaltney C. Commentary: incorporating patient-reported outcomes in periodontal clinical trials. J Periodontol. 2014 Oct;85(10):1313-9. doi: 10.1902/jop.2014.130693. Epub 2014 Jul 18.

  • Locker D, Matear D, Stephens M, Lawrence H, Payne B. Comparison of the GOHAI and OHIP-14 as measures of the oral health-related quality of life of the elderly. Community Dent Oral Epidemiol. 2001 Oct;29(5):373-81. doi: 10.1034/j.1600-0528.2001.290507.x.

  • Mei CC, Lee FY, Yeh HC. Assessment of pain perception following periodontal and implant surgeries. J Clin Periodontol. 2016 Dec;43(12):1151-1159. doi: 10.1111/jcpe.12618. Epub 2016 Nov 2.

Study Officials

  • serap karakış akcan, phd

    Beykent University

    STUDY DIRECTOR
  • berceste güler, phd

    Kutahya Health Sciences University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: The participants were defined as two study groups: Test Group (TG) consists of patients have free gingival graft around dental implant patients and Control Group (CG) consists of patients have free gingival graft around the teeth.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant professor doctor

Study Record Dates

First Submitted

March 18, 2021

First Posted

March 24, 2021

Study Start

May 1, 2017

Primary Completion

January 31, 2019

Study Completion

March 4, 2019

Last Updated

March 24, 2021

Record last verified: 2021-03

Locations