Investigation of Pectoralis Muscle Strength in Elderly With Interstitial Lung Disease

NCT04803617 | Completed

• 1 other identifier: Pectoralismajor
• Study Type: observational
• Target: 68
• Locations: 1 country
• Sites: 1

Brief Summary

Interstitial lung disease (ILD) is a restrictive lung disease characterized by impaired lung function, exercise limitation and skeletal muscle dysfunction. There is limited data on skeletal muscle function in ILD, most of which are focused on the lower limb muscles. The aim of this study were to evaluated the change of pectoralis muscle strength and relationship of pulmonary function with pectoralis muscle strength.

Conditions

Interstitial Lung Disease; Idiopathic Pulmonary Fibrosis; Sarcoidosis, Pulmonary; Geriatric

Keywords

pectoralis muscle strength; lung function test; respiratory muscle strength; horizontal adduction

Outcome Measures

Primary Outcomes (1)

• Pectoralis muscle strength test

  The pectoralis muscle strength were measured with handheld dynamometer in supine position. The shoulder joint of participant was positioned at 90º abducted and at 0º internal/external rotation and the elbow joint was flexed at 90º. The other shoulder joint was fixed by the physiotherapist. While the participant performed isometrically horizontal adduction movement, the measurement was performed on the distal part of the upper arm and the contraction was sustained for at least 5 seconds by the participant. The test was performed three times and with 60 seconds rest between tests. The mean of the best value on both sides was recorded.

  15 minute

Secondary Outcomes (5)

• FEV1

  5 minute

• FVC

  5 minute

• FEV1/FVC

  5 minute

• Respiratory muscle strength test

  15 minute

• Dyspnea assessment

  3 minute

Study Arms (2)

Patient's group

geriatric patients with interstitial lung disease

Other: Assessment of pulmonary function and pectoralis muscle strength

Control group

healthy volunteers selected from the geriatric population

Other: Assessment of pulmonary function and pectoralis muscle strength

Interventions

Assessment of pulmonary function and pectoralis muscle strength OTHER

In both groups, forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and FEV1 / FVC ratio were measured with portable spirometer according to the guidelines of the American Thoracic Society (ATS) and the European Respiratory Society (ERS). Maximal inspiratory (MIP) and expiratory pressure (MEP) were evaluated with mouth pressure device as per ATS/ERS guidelines. Sensation of dyspnea was assessed with Modified medical council research scale. Pectoralis muscle strength were measured isometrically using with digital hand held dynamometer.

Control group; Patient's group

Eligibility Criteria

• Age: 65 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The patient's group was selected from among the patients who applied to Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital. The control group was selected among volunteers invited from the local community.

You may qualify if:

• Diagnosed with ILD by a multidisciplinary team according to the 2011 ATS/ERS guidelines for ILD
• Aged 65-85

You may not qualify if:

• Uncontrolled/active cardiovascular, metabolic, systemic or cancerous disease
• Significant orthopedic, neurologic or musculoskeletal comorbidity that limited functional independence
• No being able to cooperate
• Refuse to participate in the current study

Sponsors & Collaborators

• Habibedurdu: lead

Study Sites (1)

Giresun University

Giresun, Turkey (Türkiye)

Location

Related Publications (5)

• Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, Colby TV, Cordier JF, Flaherty KR, Lasky JA, Lynch DA, Ryu JH, Swigris JJ, Wells AU, Ancochea J, Bouros D, Carvalho C, Costabel U, Ebina M, Hansell DM, Johkoh T, Kim DS, King TE Jr, Kondoh Y, Myers J, Muller NL, Nicholson AG, Richeldi L, Selman M, Dudden RF, Griss BS, Protzko SL, Schunemann HJ; ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 2011 Mar 15;183(6):788-824. doi: 10.1164/rccm.2009-040GL.

  PMID: 21471066 BACKGROUND

• Hirano M, Katoh M, Kawaguchi S, Uemura T. Intrarater reliabilities of shoulder joint horizontal adductor muscle strength measurements using a handheld dynamometer for geriatric and stroke patients. J Phys Ther Sci. 2016 Jan;28(1):51-5. doi: 10.1589/jpts.28.51. Epub 2016 Jan 30.

  PMID: 26957727 RESULT

• Panagiotou M, Polychronopoulos V, Strange C. Respiratory and lower limb muscle function in interstitial lung disease. Chron Respir Dis. 2016 May;13(2):162-72. doi: 10.1177/1479972315626014. Epub 2016 Jan 14.

  PMID: 26768011 RESULT

• Hanada M, Sakamoto N, Ishimatsu Y, Kakugawa T, Obase Y, Kozu R, Senjyu H, Izumikawa K, Mukae H, Kohno S. Effect of long-term treatment with corticosteroids on skeletal muscle strength, functional exercise capacity and health status in patients with interstitial lung disease. Respirology. 2016 Aug;21(6):1088-93. doi: 10.1111/resp.12807. Epub 2016 May 13.

  PMID: 27173103 RESULT

• Durdu H, Yurdalan SU, Ozmen I. Clinical significance of pectoralis muscle strength in elderly patients with idiopathic pulmonary fibrosis. Sarcoidosis Vasc Diffuse Lung Dis. 2022;39(1):e2022009. doi: 10.36141/svdld.v39i1.12094. Epub 2022 Mar 31.

  PMID: 35494168 DERIVED

MeSH Terms

Conditions

Lung Diseases, Interstitial; Idiopathic Pulmonary Fibrosis; Sarcoidosis, Pulmonary

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Pulmonary Fibrosis; Sarcoidosis; Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases; Hypersensitivity, Delayed; Hypersensitivity; Immune System Diseases

Study Officials

• Habibe DURDU, MSc

  Giresun University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: MSc

Study Record Dates

• First Submitted: March 13, 2021
• First Posted: March 17, 2021
• Study Start: January 23, 2017
• Primary Completion: June 23, 2017
• Study Completion: June 23, 2017
• Last Updated: March 17, 2021

Record last verified: 2021-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)