Survival Among Patients With Pancreatic Cancer Depending on Surgical Resection Rate

NCT04802993 | Completed

• 1 other identifier: 2017/151-31
• Study Type: observational
• Target: 5,123
• Locations: 0 countries
• Sites: N/A

Brief Summary

The primary aim of this population-based study is to investigate how a high resection rate of pancreaticoduodenectomy affects overall survival among patients aged ≥70 years with pancreatic ductal adenocarcinoma. The secondary aim is to determine if a high resection rate of pancreaticoduodenectomy increases perioperative morbidity.

Conditions

Pancreatic Ductal Adenocarcinoma

Keywords

pancreaticoduodenectomy

Outcome Measures

Primary Outcomes (1)

• Overall survival

  Overall survival among patients aged 70 years and over with pancreatic ductal adenocarcinoma in the pancreatic head

  A little more than 10 years (from first patient to vital status)

Secondary Outcomes (1)

• Severe complications after pancreaticoduodenectomy

  Around 10 years (patients diagnosed between 1 January 2010 and 31 December 2018, latest dismissal from hospital january 2020)

Study Arms (6)

All patients with pancreatic ductal adenocarcinoma aged 70 years and older

All patients in the registry aged 70 years and older with right-sided pancreatic ductal adenocarcinoma

Other: Resection rates

All patients with pancreatic ductal adenocarcinoma aged 70-79 years

All patients in the registry aged 70-79 years with right-sided pancreatic ductal adenocarcinoma

Other: Resection rates

All patients with pancreatic ductal adenocarcinoma aged 80 years and older

All patients in the registry aged 80 years and older with right-sided pancreatic ductal adenocarcinoma

Other: Resection rates

All patients resected with pancreaticoduodenectomy, all ages

All patients in the registry resected with pancreaticoduodenectomy during the study period

Other: Resection rates

All patients resected with pancreaticoduodenectomy, aged 70-79 years

All patients in the registry resected with pancreaticoduodenectomy during the study period, aged 70-79 years

Other: Resection rates

All patients resected with pancreaticoduodenectomy, aged 80 years and older

All patients in the registry resected with pancreaticoduodenectomy during the study period, aged 80 years and older

Other: Resection rates

Interventions

Resection rates OTHER

All groups are divided into one high- and one low resection rate group depending on percentage of patients with pancreatic ductal adenocarcinoma resected per county and year (first three groups) and resection rate of pancreaticoduodenectomy per 100 000 inhabitants per county (last three groups)

All patients resected with pancreaticoduodenectomy, aged 70-79 years; All patients resected with pancreaticoduodenectomy, aged 80 years and older; All patients resected with pancreaticoduodenectomy, all ages; All patients with pancreatic ductal adenocarcinoma aged 70 years and older; All patients with pancreatic ductal adenocarcinoma aged 70-79 years; All patients with pancreatic ductal adenocarcinoma aged 80 years and older

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients registered in the Swedish National Registry for tumours in the pancreatic and periampullary region diagnosed with right-sided pancreatic adenocarcinoma or resected with pancreaticoduodenectomy

You may qualify if:

• Diagnosed between 1 January 2010 and 31 December 2018
• Registered in the Swedish National Registry for tumours in the pancreatic and periampullary region
• Either a diagnosis of pancreatic ductal adenocarcinoma of the pancreatic head or having been resected with pancreaticoduodenectomy

You may not qualify if:

• None

Sponsors & Collaborators

• Linkoeping University: lead

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 10 Years
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Ass. Professor, senior consultant

Study Record Dates

• First Submitted: March 15, 2021
• First Posted: March 17, 2021
• Study Start: January 1, 2010
• Primary Completion: October 2, 2020
• Study Completion: October 2, 2020
• Last Updated: March 17, 2021

Record last verified: 2021-03

Data Sharing

• IPD Sharing: Will not share