Microarchitecture of Vitreoretinal Contact

NCT04802889 | Completed

• 1 other identifier: 124576
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Investigation of the vitreoretinal contact microarchitecture in the macular and paramacular zones of the human retina.

Conditions

Vitreoretinal Detachment; Vitreo-Retinal Adhesion

Keywords

internal limiting membrane; human vitreous; vitreomacular adhesion; vitreoretinal contact; vitreoretinal interface; hyalocytes; collagen

Outcome Measures

Primary Outcomes (4)

• the ILM thickness in the macular zone (foveola)

  the ILM thickness in the macular zone (foveola) in mkm by scanning electron microscopy data

  within 3 days after receiving the cadaver eyes

• superficial microstructure of ILM

  by scanning electron microscopy data

  within 3 days after receiving the cadaver eyes

• features of the structural microarchitecture of the preretinal vitreous in the macular zone

  by scanning electron microscopy data

  within 3 days after receiving the cadaver eyes

• morphofunctional features of preretinal hyalocytes.

  by scanning electron microscopy data

  within 3 days after receiving the cadaver eyes

Study Arms (1)

cadaver eyes

EXPERIMENTAL

The Central region of the retina and preretinal structures of cadaver eyes are examined

Other: scanning electron microscopy

Interventions

scanning electron microscopy OTHER

scanning electron microscopy of the сentral retina and preretinal structures

cadaver eyes

Eligibility Criteria

• Age: 35 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• eyes from donors without concomitant multiple organ pathology and ophthalmic pathology

You may not qualify if:

• eye injury, age over 45 years, concomitant multiple organ pathology, previous eye diseases

Sponsors & Collaborators

• The S.N. Fyodorov Eye Microsurgery State Institution: lead

Study Sites (1)

S.N. Fedorov Nmrc "Mntk "Eye Microsurgery"

Moscow, 127486, Russia

Location

Related Links

• Microanatomy of vitreoretinal interactions in macular and paramacular areas (article DOI: 10.17816/KMJ2019-595)
• Microanatomy of Internal Limiting Membrane (article)
• Cellular Microanatomy of Vitreoretinal Interface. Morphofunctional Identification of Epiretinal Vitreous Cells. Collagen Synthesis in Adult Human Vitreous (article)
• New Data of Mechanism in Vitreoretinal Adhesion and Posterior Vitreous Detachment in Humans (article)
• Antithesis to the thesis about fibronectin and laminin as the main components providing vitreoretinal adhesion (article)

MeSH Terms

Interventions

Microscopy, Electron, Scanning

Intervention Hierarchy (Ancestors)

Microscopy, Electron; Microscopy; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques

Study Officials

• Pavel V Lyskin, PhD

  The S.N. Fyodorov Eye Microsurgery State Institution

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD, ophthalmosurgeon

Study Record Dates

• First Submitted: December 6, 2020
• First Posted: March 17, 2021
• Study Start: January 1, 2008
• Primary Completion: January 1, 2020
• Study Completion: December 31, 2020
• Last Updated: March 17, 2021

Record last verified: 2021-03

Data Sharing

• IPD Sharing: Will not share

Locations

RU (1)