NCT04800926

Brief Summary

The purpose of this study is to assess the functional mobility and self-reported satisfaction with the Xavier electromyography hands-free wheelchair control system in comparison with a standard joystick.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
4

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jan 2019

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

December 28, 2018

Completed
14 days until next milestone

Study Start

First participant enrolled

January 11, 2019

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 30, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 30, 2019

Completed
1.4 years until next milestone

First Posted

Study publicly available on registry

March 16, 2021

Completed
Last Updated

April 1, 2024

Status Verified

March 1, 2024

Enrollment Period

10 months

First QC Date

December 28, 2018

Last Update Submit

March 28, 2024

Conditions

Outcome Measures

Primary Outcomes (1)

  • Wheelchair Skills Test (WST)

    Questionnaire

    approximately 3 days

Secondary Outcomes (1)

  • Drive test

    approximately 3 days

Study Arms (1)

Xavier wheelchair controller

EXPERIMENTAL

Surface electromyography control of wheelchair

Device: Xavier wheelchair controller

Interventions

Controlling a wheelchair using the Xavier surface EMG system

Xavier wheelchair controller

Eligibility Criteria

Age18 Years - 89 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • ALS diagnosis by revised el Escorial criteria (definite, probable or probable laboratory supported)
  • Age 18-89
  • Limited mobility with use of motorized wheelchair at screening-time
  • Impairment of hand function limiting the use of a standard joystick control
  • Caregiver willing to assist with transfers into wheelchair and application of controllers
  • Ability to attend study visits with a motorized wheelchair
  • Ability to communicate and answer patient reported outcome measure questions

You may not qualify if:

  • Cognitive impairment prohibiting safe independent mobility as defined by an ALS-Cognitive Behavioral Screen (ALS-CBS) score of \<10 or the opinion of the investigator
  • A sensory impairment prohibiting safe independent mobility in the opinion of the investigator
  • Allergy to adhesives or electrode gels (required for EMG electrodes)
  • Skin breakdown over the temporalis muscle that would predispose to further breakdown and/or infection with electrodes
  • Severe loss of facial muscle functionality or control that would preclude EMG electrode efficacy
  • Subjects who do not have the capacity to consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Mayo Clinic in Florida

Jacksonville, Florida, 32224, United States

Location

Related Publications (1)

  • Manero AC, McLinden SL, Sparkman J, Oskarsson B. Evaluating surface EMG control of motorized wheelchairs for amyotrophic lateral sclerosis patients. J Neuroeng Rehabil. 2022 Aug 14;19(1):88. doi: 10.1186/s12984-022-01066-8.

    PMID: 35965311BACKGROUND

Related Links

MeSH Terms

Conditions

Amyotrophic Lateral Sclerosis

Condition Hierarchy (Ancestors)

Spinal Cord DiseasesCentral Nervous System DiseasesNervous System DiseasesMotor Neuron DiseaseNeurodegenerative DiseasesTDP-43 ProteinopathiesNeuromuscular DiseasesProteostasis DeficienciesMetabolic DiseasesNutritional and Metabolic Diseases

Study Officials

  • Bjorn Oskarsson, MD

    Mayo Clinic

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
DEVICE FEASIBILITY
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

December 28, 2018

First Posted

March 16, 2021

Study Start

January 11, 2019

Primary Completion

October 30, 2019

Study Completion

October 30, 2019

Last Updated

April 1, 2024

Record last verified: 2024-03

Locations