Brief Summary

Background To date, most of the literature investigating the role of dietary protein in muscle growth has focused on isolated protein sources. However, dietary protein is most commonly consumed within a whole food source. Consuming dietary protein within a whole food matrix may additionally stimulate muscle growth. The idea being, there may be other components within food, capable of producing a greater response. Objectives: To assess the effect of consuming a variety of whole food sources, on the stimulation of muscle growth compared to an isolated protein source following a single bout of lower body resistance exercise. Methods Young healthy resistance-trained volunteers will consume a protein rich whole food source, following a bout of lower body resistance exercise. Stable isotope IV infusions and repeated blood and muscle samples will be taken to assess protein digestion and absorption, as well as muscle protein synthesis rates. Value of Research: To determine whether whole food sources potentiate muscle protein synthesis rates (and to what extent across whole food sources) compared to an isolated protein source. In doing so, we can further investigate the nutrients involved that may be contributing to this effect.

Trial Health

On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment

participants targeted

Target at P50-P75 for not_applicable

Timeline

Completed

Started May 2021

Typical duration for not_applicable

Geographic Reach

1 country

1 active site

Status

completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

3 years study duration

First Submitted

Initial submission to the registry

March 4, 2021

Completed

7 days until next milestone

First Posted

Study publicly available on registry

March 11, 2021

Completed

2 months until next milestone

Study Start

First participant enrolled

May 1, 2021

Completed

2.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2024

Completed

1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2024

Completed

Last Updated

May 9, 2024

Status Verified

May 1, 2024

Enrollment Period

2.9 years

First QC Date

March 4, 2021

Last Update Submit

May 8, 2024

Conditions

Nutritional Intervention Using Protein Rich Whole Food Sources

Outcome Measures

Primary Outcomes (1)

Postprandial Muscle protein Synthetic Response following the ingestion of a protein rich whole food source.
84 participants will undergo a single bout of lower body exercise followed by the ingestion of one of the six protein rich whole food sources. Using stable isotope tracer methodology and muscle biopsy samples, the postprandial muscle protein synthetic response will be able to be calculated.
2 years