Population Burden of STI and Implication for Intervention in Hong Kong

NCT04793841 | Completed

• 1 other identifier: CID-CUHK-E
• Study Type: observational
• Target: 1,977
• Locations: 1 country
• Sites: 1

Brief Summary

This is a 5-year cross-disciplinary sexually transmitted infection (STI) project involving a) territory-wide and community-based studies (survey and specimen collection); b) simulation of STI transmission dynamics and comparison of STI intervention strategies through mathematical modelling and cost-effectiveness analysis. The aim of this project is to assess the burden and the transmission dynamics of STIs in the general population and men who have sex with men (MSM) in Hong Kong. Around 1300 sexually experienced adults and 900 MSM would be recruited, 100 participants would be invited for individual in-depth interviews. Main outcome measures include STI history and service preference, effectiveness as measured by the proportion of new STI infections (chlamydia, gonorrhoea and human papillomavirus infections) averted above base-case scenario, and incremental cost-effectiveness ratio.

Conditions

STI

Keywords

chlamydia trachomatis; Neisseria gonorrhoeae; human papillomavirus; men who have sex with men; general population

Outcome Measures

Primary Outcomes (2)

• self-reported STI diagnosis in questionnaire

  number of STI diagnosis

  up to 2 years

• effectiveness of STI intervention strategies

  incremental cost-effectiveness ratio

  10 years

Secondary Outcomes (3)

• STI symptom reported in questionnaire

  12 months

• willingness to pay for STI testing reported in questionnaire

  12 months

• prevalence of STI estimated through laboratory testing

  12 months

Study Arms (2)

General population

sexually experienced adults (aged 18 or above) of the randomly selected household

Other: self-sampling kits for STI testing in laboratory

men who have sex with men

men who have sex with men aged 18 or above and normally living in Hong Kong

Other: self-sampling kits for STI testing in laboratory

Interventions

self-sampling kits for STI testing in laboratory OTHER

participants in both groups will receive self-sampling kits and deliver the collected samples to laboratory for testing

General population; men who have sex with men

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

sexually experienced adults

You may qualify if:

• aged 18 or above
• ever having sex
• normally living in Hong Kong
• can communicate in English or Chinese

You may not qualify if:

• failed to provide consent

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (1)

The Chinese University of Hong Kong

Hong Kong, Hong Kong, China, 0000, Hong Kong

Location

Biospecimen

Retention: SAMPLES WITH DNA

urine, penile swab, cervical swab, rectal swab, pharyngeal swab

MeSH Terms

Conditions

Sexually Transmitted Diseases; Homosexuality

Interventions

Laboratories

Condition Hierarchy (Ancestors)

Communicable Diseases; Infections; Genital Diseases; Urogenital Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Sexuality; Sexual Behavior; Behavior

Intervention Hierarchy (Ancestors)

Non-Medical Public and Private Facilities; Health Facilities; Health Care Facilities Workforce and Services

Study Officials

• Ngai Sze Wong, PhD

  Chinese University of Hong Kong

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: February 1, 2021
• First Posted: March 11, 2021
• Study Start: May 13, 2021
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: March 17, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

HK (1)