Singapore Perioperative Ageing Study (Sing-PAS)

NCT04792554 | Recruiting

• 1 other identifier: 2020/00152
• Study Type: observational
• Target: 600
• Locations: 1 country
• Sites: 2

Brief Summary

The specific aim of the study will be to set up a perioperative database to longitudinally track the progress of elderly patients undergoing major surgery from the preoperative period to five years postoperatively. This database will form the foundation of a programme that will be sustainable through future grants to implement clinical strategies to improve outcomes.

Conditions

Postoperative Delirium; Aging; Myocardial Injury

Keywords

Geriatrics

Outcome Measures

Primary Outcomes (1)

• Development of POD in elderly patients undergoing major non-cardiac surgery in a tertiary hospital in Singapore

  Collection of patient's demographics, medical records and surgical records to establish risk factors for POD development

  Before surgery through to 5 years post surgery

Study Arms (1)

Surgical Cohort

Elderly patients aged 65 and above who are planned for major non-cardiac surgery predicted to be at least 2 hours in duration and requiring at least 1 postoperative stay in hospital.

Other: Neurocognitive tests and blood taking

Interventions

Neurocognitive tests and blood taking OTHER

Battery of neurocognitive tests and questionnaires including MoCA, PHQ-9, Falls History, FIFE, STOPBANG, Nutritional Survey, Global Physical Activity Questionnaire, Brief Pain Index, Brief Psychiatric Rating Scale, NuDESC, 3D-CAM. Blood taking.

Surgical Cohort

Eligibility Criteria

• Age: 65 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Elderly patients aged 65 and above who are planned for major non-cardiac surgery predicted to be at least 2 hours in duration and requiring at least 1 postoperative stay in hospital.

You may qualify if:

• Elderly patients aged 65 years and above
• Undergoing major non-cardiac surgery, defined as surgery that is predicted to be at least 2 hours and requiring at least 1 day postoperative stay in the hospital
• English, Chinese or Malay speaking
• Ability to provide informed consent

You may not qualify if:

• History of psychiatric disease
• Illiterate
• An active history of substance abuse.
• Undergoing neurological procedures
• Undergoing emergency surgeries
• Has a second surgery planned within 5 days of index surgery
• Non-resident of Singapore
• Severe hearing and/or speech impairment

Sponsors & Collaborators

• National University Hospital, Singapore: lead
• National University of Singapore: collaborator

Study Sites (2)

National University Hospital

Singapore, 119074, Singapore

RECRUITING

Alexandra Hospital

Singapore, 159964, Singapore

ACTIVE NOT RECRUITING

Related Publications (4)

• Rose J, Weiser TG, Hider P, Wilson L, Gruen RL, Bickler SW. Estimated need for surgery worldwide based on prevalence of diseases: a modelling strategy for the WHO Global Health Estimate. Lancet Glob Health. 2015 Apr 27;3 Suppl 2(Suppl 2):S13-20. doi: 10.1016/S2214-109X(15)70087-2.

  PMID: 25926315 BACKGROUND

• Yang R, Wolfson M, Lewis MC. Unique Aspects of the Elderly Surgical Population: An Anesthesiologist's Perspective. Geriatr Orthop Surg Rehabil. 2011 Mar;2(2):56-64. doi: 10.1177/2151458510394606.

  PMID: 23569671 BACKGROUND

• Aldecoa C, Bettelli G, Bilotta F, Sanders RD, Audisio R, Borozdina A, Cherubini A, Jones C, Kehlet H, MacLullich A, Radtke F, Riese F, Slooter AJ, Veyckemans F, Kramer S, Neuner B, Weiss B, Spies CD. European Society of Anaesthesiology evidence-based and consensus-based guideline on postoperative delirium. Eur J Anaesthesiol. 2017 Apr;34(4):192-214. doi: 10.1097/EJA.0000000000000594.

  PMID: 28187050 BACKGROUND

• Evered L, Silbert B, Knopman DS, Scott DA, DeKosky ST, Rasmussen LS, Oh ES, Crosby G, Berger M, Eckenhoff RG; Nomenclature Consensus Working Group. Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018. Br J Anaesth. 2018 Nov;121(5):1005-1012. doi: 10.1016/j.bja.2017.11.087. Epub 2018 Jun 15.

  PMID: 30336844 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Blood samples

MeSH Terms

Conditions

Emergence Delirium

Interventions

Mental Status and Dementia Tests

Condition Hierarchy (Ancestors)

Delirium; Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Neuropsychological Tests; Psychological Tests; Behavioral Disciplines and Activities

Study Officials

• Lian Kah Ti

  National University Health System

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Lian Kah Ti

CONTACT

67724200; lian_kah_ti@nuhs.edu.sg

Lian Kah Ti

CONTACT

lian_kah_ti@nuhs.edu.sg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 8, 2021
• First Posted: March 11, 2021
• Study Start: April 7, 2021
• Primary Completion: December 1, 2025
• Study Completion (Estimated): December 1, 2026
• Last Updated: October 6, 2022

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will not share

Locations

SG (2)