Marijuana Use, Strength Training, and Alcohol Consumption (MUSTAC) Study

NCT04791917 | Completed Results

• 5 other identifiers: IRB202000058-N1F31AA028696-01A1AGR DTD 02-17-2020UFCAREDAG00200045887
• Study Type: interventional
• Target: 51
• Locations: 1 country
• Sites: 1

Brief Summary

Self-medication of pain by consuming alcohol and marijuana is common. However, the research regarding pain as a determinant for alcohol and marijuana use has relied on laboratory pain induction paradigms with limited clinical relevance. The study will assess demand for alcohol and marijuana before and after delayed onset muscle soreness (DOMS) induction in co-users. This will provide a clinically relevant, but time-limited, model for the effects of musculoskeletal pain on demand.

Conditions

Chronic Pain

Outcome Measures

Primary Outcomes (10)

• Alcohol Demand: Breakpoint

  Changes in breakpoint of alcohol demand, assessed using the Alcohol Purchase Task. Breakpoint indicates the drink price at which participants report no alcohol consumption. Values represent difference scores derived from breakpoint values coded so that positive values indicate an increase in the demand index from baseline to follow-up.

  48 hours after exercise

• Alcohol Demand: Omax

  Changes in Omax, assessed using the Alcohol Purchase Task. Omax reflects the highest total amount in dollars that a participant would spend on alcohol-containing beverages. Values represent difference scores derived from log-transformed Omax values coded so that positive values indicate an increase in the demand index from baseline to follow-up.

  48 hours after exercise

• Alcohol Demand: Pmax

  Changes in Pmax, assessed using the Alcohol Purchase Task. Pmax reflects the price point at which demand for alcohol becomes elastic (i.e., declines in response to increasing price). Values represent difference scores derived from log-transformed Pmax values coded so that positive values indicate an increase in the demand index from baseline to follow-up.

  48 hours after exercise

• Alcohol Demand: Essential Value

  Changes in Essential Value, assessed using the Alcohol Purchase Task. Essential Value represents the reinforcing efficacy of alcohol, such that higher Essential Value indicates greater reinforcing efficacy. Values represent difference scores derived from Essential Values coded so that positive numbers indicate an increase in the demand index from baseline to follow-up.

  48 hours after exercise

• Cannabis Demand: Intensity

  Changes in intensity of cannabis demand, assessed using the Marijuana Purchase Task. Intensity reflects the number of joints that would hypothetically be consumed if they were free. Values represent difference scores derived from log-transformed intensity values coded so that positive values indicate an increase in the demand index from baseline to follow-up.

  48 hours after exercise

• Cannabis Demand: Breakpoint

  Changes in breakpoint of cannabis demand, assessed using the Marijuana Purchase Task. Breakpoint indicates the joint price at which participants report no cannabis consumption. Values represent difference scores derived from breakpoint values coded so that positive values indicate an increase in the demand index from baseline to follow-up.

  48 hours after exercise

• Cannabis Demand: Omax

  Changes in Omax, assessed using the Marijuana Purchase Task. Omax reflects the highest total amount that a participant would spend on cannabis. Values represent difference scores derived from log-transformed Omax values coded so that positive values indicate an increase in the demand index from baseline to follow-up.

  48 hours after exercise

• Cannabis Demand: Pmax

  Changes in Pmax, assessed using the Marijuana Purchase Task. Pmax reflects the price point at which demand for cannabis becomes elastic (i.e., declines in response to increasing price). Values represent difference scores derived from log-transformed Pmax values coded so that positive values indicate an increase in the demand index from baseline to follow-up.

  48 hours after exercise

• Cannabis Demand: Essential Value

  Changes in Essential Value, assessed using the Marijuana Purchase Task. Essential Value represents the reinforcing efficacy of cannabis, such that higher Essential Value indicates greater reinforcing efficacy. Values represent difference scores derived from Essential Values coded so that positive numbers indicate an increase in the demand index from baseline to follow-up.

  48 hours after exercise

• Alcohol Demand: Intensity

  Changes in intensity of alcohol demand, assessed using the Alcohol Purchase Task. Intensity reflects the number of drinks that would hypothetically be consumed if they were free. Values represent difference scores derived from log-transformed number of drinks coded so that positive values indicate an increase in the demand index from baseline to follow-up.

  48 hours after exercise

Study Arms (2)

Delayed Onset Muscle Soreness Induction

EXPERIMENTAL

Participants will complete an exercise session designed to induce delayed onset muscle soreness in the biceps

Behavioral: Eccentric Biceps Flexion

Sham Delayed Onset Muscle Soreness Induction

SHAM COMPARATOR

Participants will complete an exercise session that is unlikely to induce delayed onset muscle soreness in the biceps

Behavioral: Concentric Biceps Flexion

Interventions

Eccentric Biceps Flexion BEHAVIORAL

Muscle lengthening biceps exercise

Delayed Onset Muscle Soreness Induction

Concentric Biceps Flexion BEHAVIORAL

Muscle shortening biceps exercise

Sham Delayed Onset Muscle Soreness Induction

Eligibility Criteria

• Age: 21 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥ 21 years;
• English-speaking
• Self-identify as White/Caucasian or Black/African American
• Own a smartphone with cellular/data plan
• Regularly co-use alcohol and smoked marijuana as indicated by scores of ≥3 on item 1 of the CUDIT-R and AUDIT.
• Willing and able to give informed consent

You may not qualify if:

• Participation in biceps-specific conditioning program in the past 6 months\*
• Self-reported wrist/hand, elbow, or shoulder pain the past 3 months
• Chronic medical condition that may affect pain perception (e.g. diabetes, fibromyalgia, headaches)
• Self-reported kidney dysfunction, muscle damage, or major psychiatric disorder
• Medical marijuana prescription
• Consumption of marijuana using only non-inhalational methods (e.g. edibles, tinctures, or cannabidiol oil)
• Score of ≥ 10 on Patient Health Questionnaire-9 (moderate depression)
• Women who are pregnant, trying to become pregnant, or breastfeeding

Sponsors & Collaborators

• University of Florida: lead
• National Institute on Alcohol Abuse and Alcoholism (NIAAA): collaborator
• Research Society on Alcohol: collaborator

Study Sites (1)

University of Florida Center for Pain Research and Behavioral Health

Gainesville, Florida, 32610, United States

Location

MeSH Terms

Conditions

Chronic Pain

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Results Point of Contact

• Title: Jeff Boissoneault, PhD
• Organization: University of Florida Department of Clinical and Health Psychology

jboissoneault@phhp.ufl.edu

352-273-6200

Study Officials

• Jeff Boissoneault, PhD

  University of Florida

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 9, 2021
• First Posted: March 10, 2021
• Study Start: October 28, 2020
• Primary Completion: May 10, 2022
• Study Completion: May 10, 2022
• Last Updated: July 27, 2023
• Results First Posted: July 27, 2023

Record last verified: 2023-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)