Acute-On-Chronic Liver Failure In Cirrhotic Patients

NCT04790435 | Completed

• 1 other identifier: Soh-Med-21-02-12
• Study Type: observational
• Target: 109
• Locations: 1 country
• Sites: 1

Brief Summary

Cirrhosis is a condition characterized by diffuse fibrosis, severe disruption of the intrahepatic arterial and venous flow, portal hypertension and, ultimately, liver cell failure. Traditionally, cirrhosis has been dichotomised in compensated and decompensated, and the transition to decompensated cirrhosis happens when any of the following hallmarks occurs: presence of ascites, variceal haemorrhage and/ or hepatic encephalopathy (HE) . In Egypt, HCV is the main cause of liver cirrhosis followed by HBV

Conditions

Cirrhosis, Liver

Keywords

Cirrhosis, liver failure

Outcome Measures

Primary Outcomes (1)

• Predictors of 28 day mortality rate in acute on chronic liver failure patients. with acute on top of chronic liver failure

  It will be determined by univariate and multivariate analysis.

  4 weeks from start point.

Secondary Outcomes (2)

• Triggers of development of ACLF .

  4 weeks from start point.

• Types and numbers of organ failures in patients with ACLF.

  4 weeks from start point

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Cirrhotic patients whether compensated or decompensated with an acute decompensation of cirrhosis which is defined by the recent development of ascites, encephalopathy, GI haemorrhage, bacterial infection, or any combination of these

You may qualify if:

• Cirrhotic patients whether compensated or decompensated with an acute decompensation of cirrhosis which is defined by the recent development of ascites, encephalopathy, GI haemorrhage, bacterial infection, or any combination of these

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag University

Sohag, Egypt

Location

MeSH Terms

Conditions

Liver Cirrhosis; Fibrosis; Liver Failure

Condition Hierarchy (Ancestors)

Liver Diseases; Digestive System Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Hepatic Insufficiency

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident in Tropical Medicine and Gastroenterology Department

Study Record Dates

• First Submitted: March 1, 2021
• First Posted: March 10, 2021
• Study Start: March 1, 2021
• Primary Completion: February 1, 2022
• Study Completion: February 1, 2022
• Last Updated: May 16, 2022

Record last verified: 2022-05

Locations

EG (1)