NCT04789967

Brief Summary

65% of the general population reported experiencing moderate to severe bloating symptoms. Bloating could be disturbing to patients and frustrating to the physicians as an effective treatment is still lacking. Guided Imagery (GI) involves the structured visualisation of mental images with somatic sensory; whereas Progressive Muscle Relaxation (PMR) focuses on tightening and relaxing the body's specific muscle groups. The development and validation of GI or PMR interventions to treat patients with functional abdominal bloating are relatively novel.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
96

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Feb 2021

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 25, 2021

Completed
Same day until next milestone

Study Start

First participant enrolled

February 25, 2021

Completed
13 days until next milestone

First Posted

Study publicly available on registry

March 10, 2021

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 28, 2022

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 30, 2022

Completed
Last Updated

November 9, 2022

Status Verified

November 1, 2022

Enrollment Period

1.3 years

First QC Date

February 25, 2021

Last Update Submit

November 4, 2022

Conditions

Keywords

Guided ImageryProgressive Muscle RelaxationRelaxation TechniquesPsychotherapyHypnosisSports PsychologyBloatingGastrointestinal DiseaseDistention

Outcome Measures

Primary Outcomes (1)

  • Symptoms severity

    Measured using the Malay version of Bloating Severity Questionnaire (BSQ-M). It consists of two components: five-item Sev24 and seven-item SevGen. The responses were in a multiple-choice answer format on different degrees of effect towards individuals on the basis of intensity, frequency and severity (less severe to more severe; range 1 to 4,5,6,7 or 8 varied by items). Higher scores in BSQ indicate worse severity.

    1 month

Secondary Outcomes (8)

  • Health belief

    1 month

  • Health seeking Intention

    1 month

  • Health promoting behavior

    1 month

  • Anxiety

    1 month

  • Depression

    1 month

  • +3 more secondary outcomes

Study Arms (3)

Guided Imagery (GI)

ACTIVE COMPARATOR

A 8 minute audio that focuses on evoking mental images in reducing the abdominal bloating sensation in patients

Behavioral: Guided Imagery

Progressive Muscle Relaxation (PMR)

ACTIVE COMPARATOR

A 8 minute audio that focuses on contracting certain muscle groups and relaxing it progressively in reducing the abdominal bloating sensation in patients

Behavioral: Progressive Muscle Relaxation

Audiobook

PLACEBO COMPARATOR

A 8 minute audio that focuses on providing educational information regarding functional gastrointestinal disorders and related knowledge.

Other: Educational Audiobook

Interventions

Guided ImageryBEHAVIORAL

Individualized Guided Imagery (GI) technique, an alternative type of relaxation therapy. The content of GI usually includes scenery, places or any image projected to the mind. By using information generated, participants are guided to create a place in their mind using their senses of touch, sound, smell, sight and taste.

Also known as: Imagery (Psychotherapy), Imagery, Guided, Psychotherapy Imagery, Imagery Psychotherapy
Guided Imagery (GI)

Progressive muscle relaxation (PMR) therapy works by progressively relaxing and tensing the muscle groups throughout the entire body. Each muscle group will be tensed for about 5 seconds. If there's any pain or discomfort at any of the targeted areas, participants were told to omit that particular step. Constant purposeful deep breathing was instructed throughout the session especially in between changes of muscle.

Also known as: Progressive Relaxation
Progressive Muscle Relaxation (PMR)

Participants in the control group will receive an audiobook that targets to educate patients regarding gut-brain disorders, functional gastrointestinal disorders, causes of functional abdominal bloating, and treatment modalities available. Relaxing musical background will be added to facilitate the delivery.

Audiobook

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Participants with abdominal bloating as determined using the Malay version Rome III criteria which was validated and translated by past researchers (Lee et al, 2012) and/or patients who were suggested by clinicians.
  • Participants must be 18 years and above, and of either gender.
  • Participants are able to read, write, or understand the Malay language.

You may not qualify if:

  • Patients with abdominal bloating due to organic disorder
  • Patients with recent abdominal surgeries (within 3 months) or previous major abdominal surgeries
  • Patients with major neurological and psychological disorders including stroke, schizophrenia, major depression.
  • Patients with medical history which may be the red flag for other FGIDs and organic disorders .
  • Patients who are on psychotropic medications or psychotherapy which may confound outcome of imagery of sham intervention.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Universiti Sains Malaysia

Kubang Kerian, Kelantan, 16150, Malaysia

Location

MeSH Terms

Conditions

Gastrointestinal DiseasesDilatation, Pathologic

Interventions

Imagery, PsychotherapyAutogenic Training

Condition Hierarchy (Ancestors)

Digestive System DiseasesPathological Conditions, AnatomicalPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Mind-Body TherapiesComplementary TherapiesTherapeuticsPsychotherapyBehavioral Disciplines and ActivitiesHypnosis

Study Officials

  • Vincent Tee, MD

    Universiti Sains Malaysia

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principle Investigator

Study Record Dates

First Submitted

February 25, 2021

First Posted

March 10, 2021

Study Start

February 25, 2021

Primary Completion

June 28, 2022

Study Completion

August 30, 2022

Last Updated

November 9, 2022

Record last verified: 2022-11

Data Sharing

IPD Sharing
Will not share

Locations