Long-term Prognosis of Emergency Aneurysmal Subarachnoid Hemorrhage

NCT04785976 | Recruiting DMC

• 1 other identifier: KY 2020-11-26
• Study Type: observational
• Target: 5,000
• Locations: 1 country
• Sites: 2

Brief Summary

Rupture of intracranial aneurysms can lead to extensive subarachnoid hemorrhage (SAH), a potentially fatal neurological emergency with mortality rates ranging from 8 to 67%. At present, surgical clipping (SC) and endovascular coiling (EC) are two main treatments for aneurysmal subarachnoid hemorrhage (aSAH), in recent years, the improvements in surgical equipment and techniques have already greatly improved the postoperative safety of patients. However, considering individual differences between patients, some still at risk due to possible complications during hospitalization or after discharge from the hospital, it will no doubt generate a large healthcare burden. This prospective, observational clinical trial (LongTEAM) is to improve the diagnosis and treatment effect and efficiency in this field, reducing mortality, medical costs, and medical burden, while opening up new avenues for interdisciplinary clinical practice and scientific research exploration.

Conditions

Aneurysmal Subarachnoid Hemorrhage

Outcome Measures

Primary Outcomes (5)

• Unfavorable neurological outcome (mRS>2)

  Number of patients experiencing a unfavorable neurological outcome at discharge, defined as a modified Rankin Scale (mRS) score of \>2.

  10 days after the procedure

• Unfavorable neurological outcome (mRS>2)

  Number of patients experiencing a unfavorable neurological outcome at 3 months post-treatment, defined as a modified Rankin Scale (mRS) score of \>2.

  3 months

• Unfavorable neurological outcome (mRS>2)

  Number of patients experiencing a unfavorable neurological outcome at 6 months post-treatment, defined as a modified Rankin Scale (mRS) score of \>2.

  6 months

• Unfavorable neurological outcome (mRS>2)

  Number of patients experiencing a unfavorable neurological outcome at 12 months post-treatment, defined as a modified Rankin Scale (mRS) score of \>2.

  12 months

• Unfavorable neurological outcome (mRS>2)

  Number of patients experiencing a unfavorable neurological outcome at 24 months post-treatment, defined as a modified Rankin Scale (mRS) score of \>2.

  24 months

Secondary Outcomes (10)

• Cognitive deficits

  10 days after the procedure

• Cognitive deficits

  3 months

• Cognitive deficits

  6 months

• Cognitive deficits

  12 months

• Cognitive deficits

  24 months

Study Arms (2)

Surgical clipping

Procedure: Surgical clipping and endovascular coiling

Endovascular coiling

Procedure: Surgical clipping and endovascular coiling

Interventions

Surgical clipping and endovascular coiling PROCEDURE

Surgical clipping: Apply aneurysm clip to clip the ruptured aneurysm. Endovascular coiling：Also called endovascular embolization, to block blood flow into an aneurysm.Preventing blood flow into an aneurysm helps to keep it from rupturing.

Endovascular coiling; Surgical clipping

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients admitted to the emergency department of the investigator with aneurysmal subarachnoid hemorrhage are included in their prospective registry

You may qualify if:

• All patients admitted to the emergency department of the investigator with aneurysmal subarachnoid hemorrhage are included in their prospective registry.

You may not qualify if:

• None

Sponsors & Collaborators

• Beijing Tiantan Hospital: lead
• Peking University International Hospital: collaborator

Study Sites (2)

Beijing Tiantan Hospital

Beijing, Beijing Municipality, 100070, China

RECRUITING

The First People's Hospital of Neijiang

Neijiang, Sichuan, China

RECRUITING

Related Publications (9)

• Tang X, Wang X, Zhu B, Zhou L, Chen X. The prognostic significance of uric acid to albumin ratio in patients with aneurysmal subarachnoid hemorrhage following surgical clipping or endovascular interventions: insights from a large cohort study. Front Neurol. 2026 Jan 12;16:1648805. doi: 10.3389/fneur.2025.1648805. eCollection 2025.

  PMID: 41602990 DERIVED

• Yu T, Lau TY, Liu Y, Li R, Lin F, Song Z, Zhu Q, Chen Y, Li T, Jing J, Chen X. Low-Field Portable MRI Detects Developmental Pattern of Ultraearly Cerebral Infarction in aSAH. Stroke. 2025 Dec 11. doi: 10.1161/STROKEAHA.125.052474. Online ahead of print.

  PMID: 41376582 DERIVED

• Tang X, Zhu B, Liu M, Lin F, Li R, Song W, Xue J, Zhou L, Chen X. Increased triglyceride-glucose index is associated with adverse functional outcome for patients with aneurysmal subarachnoid hemorrhage after surgical clipping and endovascular coiling: insights from a large cohort study. Front Neurol. 2025 Sep 10;16:1622819. doi: 10.3389/fneur.2025.1622819. eCollection 2025.

  PMID: 41001201 DERIVED

• Yang Y, Zhu B, Lin F, Li R, Chen X. Association between geriatric nutritional risk index and clinical outcome of elderly aneurysmal subarachnoid hemorrhage patients: insights from a large cohort study. Neurosurg Rev. 2025 Feb 4;48(1):169. doi: 10.1007/s10143-025-03209-6.

  PMID: 39903290 DERIVED

• Li R, Lin F, Chen Y, Lu J, Yang J, Han H, Yuan K, Wang K, Yan D, Li R, He S, Li Z, Zhang H, Chen X, Ma L, Zhao Y, Hao Q, Ye X, Wang H, Li H, Zhang L, Shi G, Zhou J, Li Y, Wang S, Chen X, Zhao Y. The effect of sex differences on complications and 90-day outcomes after aneurysmal subarachnoid hemorrhage: a propensity score-matched analysis. Neurosurg Rev. 2022 Oct;45(5):3339-3347. doi: 10.1007/s10143-022-01836-x. Epub 2022 Jul 23.

  PMID: 35870093 DERIVED

• Li R, Lin F, Chen Y, Lu J, Han H, Ma L, Zhao Y, Yan D, Li R, Yang J, He S, Li Z, Zhang H, Yuan K, Wang K, Hao Q, Ye X, Wang H, Li H, Zhang L, Shi G, Zhou J, Zhao Y, Zhang Y, Li Y, Wang S, Chen X, Zhao Y. A 90-Day Prognostic Model Based on the Early Brain Injury Indicators after Aneurysmal Subarachnoid Hemorrhage: the TAPS Score. Transl Stroke Res. 2023 Apr;14(2):200-210. doi: 10.1007/s12975-022-01033-4. Epub 2022 May 14.

  PMID: 35567655 DERIVED

• Li R, Lin F, Chen Y, Lu J, Han H, Ma L, Zhao Y, Yan D, Li R, Yang J, He S, Li Z, Zhang H, Yuan K, Wang K, Hao Q, Ye X, Wang H, Li H, Zhang L, Shi G, Zhou J, Zhao Y, Zhang Y, Li Y, Wang S, Chen X, Zhao Y. Elevated blood hemoglobin on admission as an independent predictor of unfavorable outcomes in patients with aneurysmal subarachnoid hemorrhage. Neurosurg Rev. 2022 Aug;45(4):2689-2699. doi: 10.1007/s10143-022-01780-w. Epub 2022 Apr 2.

  PMID: 35366711 DERIVED

• Yang J, Lu J, Li R, Lin F, Chen Y, Han H, Yan D, Li R, Li Z, Zhang H, Yuan K, Li H, Zhang L, Shi G, Zhou J, Wang S, Zhao Y, Chen X. Application of Intracranial Pressure-Directed Therapy on Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage. Front Aging Neurosci. 2022 Mar 14;14:831994. doi: 10.3389/fnagi.2022.831994. eCollection 2022.

  PMID: 35360218 DERIVED

• Lin F, Chen Y, He Q, Zeng C, Zhang C, Chen X, Zhao Y, Wang S, Zhao J. Prognostic Value of Elevated Cardiac Troponin I After Aneurysmal Subarachnoid Hemorrhage. Front Neurol. 2021 May 31;12:677961. doi: 10.3389/fneur.2021.677961. eCollection 2021.

  PMID: 34135855 DERIVED

MeSH Terms

Conditions

Subarachnoid Hemorrhage

Condition Hierarchy (Ancestors)

Intracranial Hemorrhages; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Fa Lin, MD

  Beijing Tiantan Hospital

  PRINCIPAL INVESTIGATOR

• Yuanli Zhao, MD

  Beijing Tiantan Hospital

  STUDY CHAIR

• Jizong Zhao, MD

  Beijing Tiantan Hospital

  STUDY CHAIR

• Runting Li, MD

  Beijing Tiantan Hospital

  PRINCIPAL INVESTIGATOR

• Xiaolin Chen, MD

  Beijing Tiantan Hospital

  STUDY DIRECTOR

• Yu Chen, MD

  Beijing Tiantan Hospital

  PRINCIPAL INVESTIGATOR

• Junlin Lu, MD

  Beijing Tiantan Hospital

  PRINCIPAL INVESTIGATOR

• Zhipeng Li, MD

  Beijing Tiantan Hospital

  PRINCIPAL INVESTIGATOR

• Heze Han, MD

  Beijing Tiantan Hospital

  PRINCIPAL INVESTIGATOR

• Debin Yan, MD

  Beijing Tiantan Hospital

  PRINCIPAL INVESTIGATOR

• Shuo Wang, MD

  Beijing Tiantan Hospital

  STUDY CHAIR

Central Study Contacts

Runting Li, MD

CONTACT

+8615753166690; 1011168227@qq.com

Xiaolin Chen, MD

CONTACT

+8613810624845; xiaolinchen488@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of Department of Cerebrovascular Neurosurgery

Study Record Dates

• First Submitted: February 1, 2021
• First Posted: March 8, 2021
• Study Start: April 1, 2012
• Primary Completion (Estimated): March 1, 2032
• Study Completion (Estimated): April 1, 2032
• Last Updated: December 1, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: 6 months after the study ended
• Access Criteria: The IPD of this study are available from the principal investigator upon reasonable request.

Locations

CN (2)