Prolactin Hormone in Oral Lichen Planus
1 other identifier
observational
40
1 country
1
Brief Summary
Oral lichen planus (OLP) is one of the most common mucosal diseases with autoimmune etio-pathogenesis with involvement of various cytokines similar to psoriasis.It generally occurs more commonly in females, in a ratio of 3:2. prolactin (PRL),It is a peptide hormone that has a role in autoimmune related diseases like systemic lupus erythematosus and , rheumatoid Artheritis. The role of PrL in OLP pathogenesis was never investigated.the aim of this study is to investigate the expression of PRL receptors in tissue biopsies of OLP patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jun 2020
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 19, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 22, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
December 10, 2020
CompletedFirst Submitted
Initial submission to the registry
March 3, 2021
CompletedFirst Posted
Study publicly available on registry
March 8, 2021
CompletedMarch 8, 2021
March 1, 2021
2 months
March 3, 2021
March 3, 2021
Conditions
Outcome Measures
Primary Outcomes (1)
prolactin receptors expression in oral mucous membrane
immuno-histochemistry
24 hours
Study Arms (1)
oral lichen planus group
patients with chronic bollus erosive lichen planus
Eligibility Criteria
Egyptian patients with OLP
You may qualify if:
- patients with oral lichen planus
- systemically healthy
You may not qualify if:
- oral lichenoid lesions
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
October University for modern sciences and arts
Giza, Egypt
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- professor
Study Record Dates
First Submitted
March 3, 2021
First Posted
March 8, 2021
Study Start
June 19, 2020
Primary Completion
August 22, 2020
Study Completion
December 10, 2020
Last Updated
March 8, 2021
Record last verified: 2021-03