COVID-19 Infections and Mortality in Long-term Care Facilities During the First Wave

NCT04782427 | Completed

• 1 other identifier: CentreSuddeMontréal
• Study Type: observational
• Target: 1,197
• Locations: 1 country
• Sites: 1

Brief Summary

The medical charts of all COVID-19 cases (n=1200) from 17 long-term care facilities in Montreal, Canada will be reviewed, to compare patients who survived to patients who did not survive. Through multilevel logistic regression, the risk of death will be estimated for institutional predictors of mortality, while controlling for individual risk factors. Individual covariates include clinical features (age, sex, Charlston comorbidity index, SMAF autonomy score, severity criteria) and medical treatments (IV fluids, anticoagulation, oxygen, regular opiates, corticosteroids). Aggregate covariates include epidemiological data (attack rates, timing of outbreak) and institutional characteristics (number of beds, air exchange per hour, presence of a dedicated COVID-19 unit at the time of outbreak, staff compliance to infection control measures, staff infection rates, understaffing, proportion of semi-private rooms, proportion of wandering wards and other special units).

Conditions

Covid19; Death; Infection Viral; Infections, Respiratory; Infection, Coronavirus; Elderly Infection; Old Age; Dementia; Epidemic Disease

Outcome Measures

Primary Outcomes (1)

• Death

  COVID-19 as a primary or secondary cause of death

  28 days

Interventions

COVID-19 infection OTHER

Case of nosocomial infection within the long-term care facility

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Most of the residents living in the long-term care facilities are elderly and frail, with a high prevalence of major neurocognitive disorders and low life expectancy. However, some patients are more robust (e.g. residents of wandering wards) or younger (e.g. residents with heavy neurological or mental health diagnoses).

You may qualify if:

• Resident of a long-term care facility within the CIUSSS Centre-Sud-de-l'Île-de-Montréal
• Nosocomial COVID-19 infection diagnosis between March 23rd and July 11th 2020

You may not qualify if:

• Admission to the long-term care facility after July 11th 2020
• COVID-19 infection which was not acquired within the long-term care facility

Sponsors & Collaborators

• Centre integre universitaire de sante et de services sociaux du Centre-Sud-de-l'Île-de-Montréal: lead
• Université de Montréal: collaborator

Study Sites (1)

CIUSSS Centre-Sud-de-l'Île-de-Montréal

Montreal, Quebec, H2L 4M1, Canada

Location

MeSH Terms

Conditions

COVID-19; Death; Virus Diseases; Respiratory Tract Infections; Coronavirus Infections; Alzheimer Disease

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Study Officials

• Sophie Zhang, M.D.

  Université de Montréal

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head physician of long-term care facilities and researcher

Study Record Dates

• First Submitted: March 2, 2021
• First Posted: March 4, 2021
• Study Start: January 1, 2021
• Primary Completion: April 13, 2021
• Study Completion: May 13, 2021
• Last Updated: July 28, 2021

Record last verified: 2021-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
• Time Frame: At the time of publication, for 5 years.
• Access Criteria: Written request submitted to the principal investigator.

Locations

CA (1)