Evaluation of Musculoskeletal System Symptoms and Biochemical Parameters in COVID-19

NCT04780555 | Completed

• 1 other identifier: AIBU-FTR-EY-02
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

The neutrophil-lymphocyte ratio (NLR) used to demonstrate inflammatory status in recent years can be calculated by dividing the absolute neutrophil count by the absolute lymphocyte count at routine blood tests.

Conditions

Covid19

Keywords

pain

Outcome Measures

Primary Outcomes (3)

• Neutrophil-lymphocyte ratio (NLR)

  It can be calculated by dividing the absolute neutrophil count by the absolute lymphocyte count at routine blood tests

  Baseline

• D-dimer

  Peripheral venous blood specimens were collected using standard surgical procedures

  Baseline

• Fibrinogen

  Peripheral venous blood specimens were collected using standard surgical procedures

  Baseline

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients aged 18-65 and diagnosed with COVID-19 will be included in the study.

You may qualify if:

• Aged 18-70
• Diagnosed with COVID-19

You may not qualify if:

• Musculoskeletal pains in the previous three months, with diseases capable of causing myalgia prior to diagnosis (such as fibromyalgia and inflammatory muscle disease)
• Cognitive disorders capable of preventing history-taking and physical examination such as mental disability and dementia,
• previous history of headache (migraine, tension type headache)

Sponsors & Collaborators

• Abant Izzet Baysal University: lead

Study Sites (1)

Elif Yakşi

Merkez, Bolu, 14030, Turkey (Türkiye)

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Peripheral venous blood specimens will be collected using standard surgical procedures during presentation and were investigated in the Abant İzzet Baysal University Medical Faculty central laboratory. Complete blood count parameters (hemoglobin, leukocytes, erythrocytes, platelets, and leukocyte subtypes) will be analyzed using a Syxmex XN-1000 (Kobe, Japan) automatic analyzer. D-dimer and fibrinogen parameters will be measured on a Sysmex CS-2500 (Kobe, Japan) device, and biochemical parameters (CRP, ferritin, procalcitonin, LDH, troponin) on an automatic biochemical analyzer (Abbott Architect C8000, USA). In addition, the NLR will be calculated by dividing the absolute neutrophil count by the absolute lymphocyte count.

MeSH Terms

Conditions

COVID-19; Pain

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Nalan Doğan, MD

  Beykoz State Hospital

  PRINCIPAL INVESTIGATOR

• Dursun Karakaş, MD

  Sancaktepe Şehit İlhan Varank Research Hospital

  PRINCIPAL INVESTIGATOR

• Osman Yakşi, MD

  Abant İzzet Baysal University Medical Faculty

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor

Study Record Dates

• First Submitted: February 21, 2021
• First Posted: March 3, 2021
• Study Start: March 1, 2021
• Primary Completion: July 25, 2021
• Study Completion: August 1, 2021
• Last Updated: August 3, 2021

Record last verified: 2021-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)