Chronic Kidney Disease and Non-alcoholic Fatty Liver Diseases

NCT04779905 | Completed

• 1 other identifier: Soh-Med-21-02-40
• Study Type: observational
• Target: 62
• Locations: 1 country
• Sites: 1

Brief Summary

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. This disease reportedly affects up to 30% of the general population in Western countries, especially in patients with metabolic syndrome, obesity, and type II diabetes. NAFLD is considered to be an independent risk factor for cardiovascular disease and there is accumulating evidence to support a causative role in the development of chronic kidney disease (CKD). So, we aim first to assess the prevalence of chronic kidney disease in NAFLD patients, secondly to detect the association between hepatic fibrosis and CKD in NAFLD patients

Conditions

Chronic Kidney Diseases; NAFLD

Keywords

chronic kidney disease; NAFLD; Hepatic fibrosis

Outcome Measures

Primary Outcomes (2)

• prevalence of chronic kidney disease in nafld patient

  February 2021 to July 2021

• correlation of chronic kidney disease and degree of hepatic fibrosis in nafld patient

  February 2021 to July 2021

Study Arms (2)

Non-alcoholic Fatty Liver Diseases

patients diagnosed to has NAFLD by ultrasonography presented to the outpatient clinic of Sohag University Hospital

Diagnostic Test: urinary albumbin/creatinine ratio

control

healthy volunteers who looks normal on ultrasonography

Diagnostic Test: urinary albumbin/creatinine ratio

Interventions

urinary albumbin/creatinine ratio DIAGNOSTIC_TEST

detection of microalbuminuria in nafld patients

Also known as: estimated glomerular filtration rate

Non-alcoholic Fatty Liver Diseases; control

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This study will be conducted on 100 patients 70 patients diagnosed to has NAFLD by ultrasonography presented to the outpatient clinic of Sohag University Hospital, and A control group of 30 healthy volunteers who looks normal on ultrasonography from February 2021 to July 2021

You may qualify if:

• patients diagnosed to has NAFLD by ultrasonography presented to the outpatient clinic of Sohag University Hospital

You may not qualify if:

• Diabetic patients.
• Hypertensive patients.
• Other causes of chronic liver disease rather than NAFLD.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Mona Mohammed Abdelrahman

Sohag, Egypt

Location

Related Publications (4)

• Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther. 2011 Aug;34(3):274-85. doi: 10.1111/j.1365-2036.2011.04724.x. Epub 2011 May 30.

  PMID: 21623852 BACKGROUND

• Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, Charlton M, Sanyal AJ. The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology. 2012 Jun;55(6):2005-23. doi: 10.1002/hep.25762. No abstract available.

  PMID: 22488764 BACKGROUND

• Loomba R, Sanyal AJ. The global NAFLD epidemic. Nat Rev Gastroenterol Hepatol. 2013 Nov;10(11):686-90. doi: 10.1038/nrgastro.2013.171. Epub 2013 Sep 17.

  PMID: 24042449 BACKGROUND

• McCullough K, Sharma P, Ali T, Khan I, Smith WC, MacLeod A, Black C. Measuring the population burden of chronic kidney disease: a systematic literature review of the estimated prevalence of impaired kidney function. Nephrol Dial Transplant. 2012 May;27(5):1812-21. doi: 10.1093/ndt/gfr547. Epub 2011 Sep 29.

  PMID: 21965592 BACKGROUND

MeSH Terms

Conditions

Renal Insufficiency, Chronic; Non-alcoholic Fatty Liver Disease; Liver Cirrhosis

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Fatty Liver; Liver Diseases; Digestive System Diseases; Fibrosis

Study Officials

• Radwa Farag, MD

  Sohag University

  STUDY CHAIR

• Mohamed Amin, MD

  Sohag University

  STUDY CHAIR

• Shimaa Hemdan, MD

  Sohag University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: February 26, 2021
• First Posted: March 3, 2021
• Study Start: February 28, 2021
• Primary Completion: July 30, 2021
• Study Completion: September 15, 2021
• Last Updated: November 2, 2021

Record last verified: 2021-11

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)