Role of Ultrasound Assessment of Parasternal Intercostal Muscle Thickness During Weaning From Mechanical Ventilation

NCT04779463 | Unknown

• 1 other identifier: Parasternal Intercostals US
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Assessment of the the parasternal intercostal muscles thickness by the ultrasonography as a weaning predictor of the mechanically ventilated patients

Conditions

Parasternal Intercostal Muscle Thickness; Weaning From Mechanical Ventilation

Keywords

mechanical ventilation, parasternal muscle thickness

Outcome Measures

Primary Outcomes (1)

• the thickness fraction of the parasternal intercostal muscle as a predictor of successful spontaneous breathing trials

  The primary outcome is to assess the change of the parasternal intercostal muscles thickness at end of expiration and end of inspiration to verify the thickness fraction of the parasternal intercostal muscle as a predictor of successful spontaneous breathing trials.

  Before the start spontaneous breathing trial

Study Arms (1)

Mechanical Ventilated patients

All patients are invasively mechanically ventilated at least 24 hours, and are clinically stable as ready to undergo a spontaneous breathing trial.

Diagnostic Test: Parasternal intercostal muscles thickness ultrasound indicies

Interventions

Parasternal intercostal muscles thickness ultrasound indicies DIAGNOSTIC_TEST

Parasternal intercostal muscles thickness ultrasound indicies includes: * Parasternal Intercostals Thickness Fraction. * Parasternal Intercostals Thickness at the End of Inspiration. * Parasternal Intercostals thickness at the End of Expiration.

Also known as: Diaphragmatic thickness

Mechanical Ventilated patients

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All patients are invasively mechanically ventilated at least 24 hours, and are clinically stable as ready to undergo a spontaneous breathing trial (SBT).

You may qualify if:

• Any patient invasively mechanically ventilated at least 24 hours on a pressure support mode who is clinically stable and ready to undergo a spontaneous breathing trial.
• All patients will be:
• Alert.
• Afebrile.
• Adequate cough with absence of excessive tracheobronchial secretion.
• Fraction of inspired oxygen (FIO2) of \<50%.
• PEEP ≤8 cmH2O.
• PaO2/FiO2 \> 150.
• pH ≥7.35 and ≤7.45.
• Respiratory rate (RR) ≤35 breaths/min.
• Hemodynamically stable in the absence of vasopressors.
• Stable metabolic and endocrinal status.
• Euglycemic state.
• Adequate mentation (no sedation or stable neurologic patient).

You may not qualify if:

• Diaphragmatic paralysis (detected by ultrasonography).Patients\&Methods. 6
• Pregnant women.
• Age: \>= 18 years.
• Surgical dressings over measurement point which would preclude ultrasound exam.
• Underweight patients (Body mass index \<18.5 kg/m2).
• Morbidly obese patient (Body mass index ≥ 40 kg/m2).
• Primary neuro-muscular diseases.
• Central coditions with depressed central respiratory drive (encephalitis, and brainstem haemorrhage/ischaemia).
• Repiratory conditions with reduced pulmonary compliance (interstitial lung disease, pulmonary hemorrhage, and diffuse pulmonary infiltrates) or reduced chest wall compliance (kyphoscoliosis).
• Cardiac conditions with high risk of weaning induced pulmonary edema (congestive heart failure, cyanotic heart diease, pulmonary hypertension, and ischemic heart diease).
• Addict patients.
• Patients with psychiatric disease.

Sponsors & Collaborators

• Wesameldin Abelrahman Soltan: lead

Study Sites (1)

Faculty of Medicine - Menoufia University

Shibīn al Kawm, Menoufia, 32511, Egypt

RECRUITING

Study Officials

• Wesameldin A Soltan, M.D.

  faculty of medicine, Menoufia University

  STUDY DIRECTOR

Central Study Contacts

Wesameldin A Soltan, M.D.

CONTACT

0020101012215; wesamsultan1@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: February 27, 2021
• First Posted: March 3, 2021
• Study Start: June 1, 2020
• Primary Completion: March 1, 2021
• Study Completion: April 1, 2021
• Last Updated: March 3, 2021

Record last verified: 2021-02

Locations

EG (1)