Non-Invasive Measurement of SjvO2 Using Near Infrared Spectroscopy in Patients Undergoing Liver Transplantation Surgery

NCT04778150 | Completed

• 1 other identifier: SJVO2 vs SVO2
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Mixed venous oxygen saturation (SvO2) is an important parameter in the management of patient during liver transplantation surgery especially during portal vein clamping. The only way to measure it is to use a pulmonary artery catheter. If the authors can show a positive relationship between invasive SvO2 measurement and noninvasive jugular venous oxygen saturation (SjvO2) measurement with VO 100 medical device, it will possible to use SjvO2 as a noninvasive surrogate of SvO2 in patients during liver transplantation surgery.

Conditions

Impaired Oxygen Delivery; Transplant; Failure, Liver

Keywords

SvO2; SjvO2; Portal vein clamping; Liver transplantation surgery

Outcome Measures

Primary Outcomes (1)

• Comparison of venous oxygen saturation

  Comparison of SvO2 values from pulmonary artery catheter blood and SjvO2 values from the VO 100 (% oxygen saturation)

  Continuously during liver transplantation surgery

Interventions

VO 100 medical device from Mespere LifeSciences DEVICE

The investigators want to show a positive relationship between SjvO2 and SvO2 in order to possibly use in the future SjvO2 measured by VO 100 as a noninvasive surrogate of SvO2 in patients undergoing liver transplantation surgery.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients undergoing liver transplantation surgery for whom measurement of SvO2 is required especially during portal vein clamping.

You may qualify if:

• Adult patients routinely equipped with a pulmonary artery catheter just before liver transplantation surgery allowing SvO2 measurement.

You may not qualify if:

• Adult patients not equipped with pulmonary artery catheter for liver transplantation surgery.

Sponsors & Collaborators

• University Hospital, Geneva: lead

Study Sites (1)

University of Geneva

Geneva, 1211, Switzerland

Location

Study Officials

• Eduardo Schiffer, MD

  Head of anesthesia for liver transplantation surgery

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD

Study Record Dates

• First Submitted: February 26, 2021
• First Posted: March 2, 2021
• Study Start: June 1, 2023
• Primary Completion: October 30, 2023
• Study Completion: January 30, 2024
• Last Updated: May 8, 2024

Record last verified: 2022-05

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)