Failure Analysis of Patellofemoral Arthroplasty

NCT04772625 | Active Not Recruiting FDA Device

• 1 other identifier: PFA_Failure_06
• Study Type: observational
• Target: 550
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the retrospective cohort study is 1) to determine preoperative risk factors for revision af patellofemoral arthroplasty, and 2) to provide a detailed description of indications for revision after patellofemoral arthroplasty. All patients operated with patellofemoral arthroplasty in Denmark from January 1, 2008 to December 31, 2015, will be included in the cohort.

Conditions

Patellofemoral Osteoarthritis; Arthroplasty Complications; Knee Osteoarthritis

Keywords

Patellofemoral arthroplasty; Knee revision surgery; Indication

Outcome Measures

Primary Outcomes (1)

• Implant revision and reoperation rates

  The proportion of revised and reoperated patients

  10-year

Secondary Outcomes (1)

• The 6-year cumulative revision rate

  6 years

Study Arms (1)

PFA

The cohort consists of all patients operated with patellofemoral arthroplasty for isolated patellofemoral osteoarthritis in Denmark from Jan 1 2008 to Dec 31 2015. The number of patients is expected to be around 500. A patellofemoral arthroplasty is defined as an arthroplasty consisting of a metal trochlear component and a polyethylene patella component. The definition of isolated patellofemoral osteoarthritis in the study is pragmatic and given by the operating surgeon.

Device: Patellofemoral arthroplasty

Interventions

Patellofemoral arthroplasty DEVICE

Insertion of an artificial joint between the front of the femur and the back of the patella. The femoral component consists of a metal implant, and the patellar component is a polyethylene implant. The two components replace the original articular cartilage of the patellofemoral joint.

Also known as: Artificial joint between knee cap and thigh bone

PFA

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients operated with patellofemoral arthroplasty for patellofemoral osteoarthritis.

You may qualify if:

• Patellofemoral arthroplasty
• Primary procedure performed between Jan 1 2008 and Dec 31 2015
• Primary procedure performed in Denmark

You may not qualify if:

• Patella-nail syndrome
• Dislocating tendon following patellectomy.

Sponsors & Collaborators

• Anders Odgaard: lead
• Stryker Orthopaedics: collaborator

Study Sites (1)

Rigshospitalet

Copenhagen, 2100, Denmark

Location

Related Publications (6)

• Odgaard A, Madsen F, Kristensen PW, Kappel A, Fabrin J. The Mark Coventry Award: Patellofemoral Arthroplasty Results in Better Range of Movement and Early Patient-reported Outcomes Than TKA. Clin Orthop Relat Res. 2018 Jan;476(1):87-100. doi: 10.1007/s11999.0000000000000017.

  PMID: 29529622 BACKGROUND

• Bendixen NB, Eskelund PW, Odgaard A. Failure modes of patellofemoral arthroplasty-registries vs. clinical studies: a systematic review. Acta Orthop. 2019 Oct;90(5):473-478. doi: 10.1080/17453674.2019.1634865. Epub 2019 Jul 1.

  PMID: 31259645 BACKGROUND

• Odgaard A, Eldridge J, Madsen F. Patellofemoral Arthroplasty. JBJS Essent Surg Tech. 2019 Apr 24;9(2):e15. doi: 10.2106/JBJS.ST.18.00094. eCollection 2019 Jun 26.

  PMID: 31579533 BACKGROUND

• Fredborg C, Odgaard A, Sorensen J. Patellofemoral arthroplasty is cheaper and more effective in the short term than total knee arthroplasty for isolated patellofemoral osteoarthritis: cost-effectiveness analysis based on a randomized trial. Bone Joint J. 2020 Apr;102-B(4):449-457. doi: 10.1302/0301-620X.102B4.BJJ-2018-1580.R3.

  PMID: 32228074 BACKGROUND

• Odgaard A, Kappel A, Madsen F, Kristensen PW, Stephensen S, Attarzadeh AP. Patellofemoral Arthroplasty Results in Better Time-weighted Patient-reported Outcomes After 6 Years than TKA: A Randomized Controlled Trial. Clin Orthop Relat Res. 2022 Sep 1;480(9):1707-1718. doi: 10.1097/CORR.0000000000002178. Epub 2022 Mar 21.

  PMID: 35315804 BACKGROUND

• Rasmussen LE, Hoffmann AG, Blanche P, Espersen F, Justesen TF, Rasmussen LE, Hangaard S, Christensen R, Odgaard A. Surgeon Training and Revision Rates After Patellofemoral Arthroplasty. JAMA Netw Open. 2025 Jun 2;8(6):e2517825. doi: 10.1001/jamanetworkopen.2025.17825.

  PMID: 40577013 BACKGROUND

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Officials

• Anders Odgaard, MD, DMSc

  Rigshospitalet, Denmark

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 24, 2021
• First Posted: February 26, 2021
• Study Start: January 1, 2019
• Primary Completion: November 9, 2022
• Study Completion: April 1, 2026
• Last Updated: July 30, 2025

Record last verified: 2025-07

Locations

DK (1)