Sarcopenia and Mechanical Ventilation in Older Patients Admitted Due to COVID-19

NCT04772586 | Completed

• 1 other identifier: SARCO-V_2020/110
• Study Type: observational
• Target: 46
• Locations: 1 country
• Sites: 1

Brief Summary

The SarcoV study aims at assessing the association between sarcopenia and the indication of mechanical ventilation in older hospitalized patients due to COVID-19 infection

Conditions

Sarcopenia

Keywords

Sarcopenia; Mechanical ventilation; Older patients; COVID-19

Outcome Measures

Primary Outcomes (1)

• Indication of mechanical ventilation

  Association between probable sarcopenia and the indication of mechanical ventilation in patients with COVID-19 infection. Mechanical ventilation was considered by non-invasive ventilation or invasive ventilation. For purpose of analysis, it was defined as a binary outcome (yes(no). Probable sarcopenia probable was defined according to the revised European consensus on definition and diagnosis of sarcopenia (EWGSOP2). For purpose of analysis, it was defined as a binary condition (yes/no).

  Through study completion, an average of 60 days

Secondary Outcomes (2)

• Evaluate difficult-to-wean in mechanical ventilation

  Through study completion, an average of 60 days

• All-cause mortality

  Through study completion, an average of 60 days

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged 60 and older admitted in an acute care unit of Brugmann university hospital due to COVID-19

You may qualify if:

• Consecutive patients aged 60 and older
• Admission in an acute care unit in Brugmann university hospital due to a COVID-19 possible or confirmed infection. A infection was considered confirmed in presence of a positive molecular test by Polymerase-chain reaction (PCR), following the Belgian Public Health Department recommendations (Sciensano recommendations).

You may not qualify if:

• Patients unable to perform a grip-strength measurement due to any rheumatological or neurological condition.

Sponsors & Collaborators

• Brugmann University Hospital: lead

Study Sites (1)

Brugmann university hospital

Brussels, 1020, Belgium

Location

Related Publications (2)

• Kou HW, Yeh CH, Tsai HI, Hsu CC, Hsieh YC, Chen WT, Cheng HT, Yu MC, Lee CW. Sarcopenia is an effective predictor of difficult-to-wean and mortality among critically ill surgical patients. PLoS One. 2019 Aug 8;14(8):e0220699. doi: 10.1371/journal.pone.0220699. eCollection 2019.

  PMID: 31393937 BACKGROUND

• Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyere O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019 Jul 1;48(4):601. doi: 10.1093/ageing/afz046. No abstract available.

  PMID: 31081853 BACKGROUND

Related Links

• Definition of a confirmed COVID-19 case and National recommendations for the request of PCR test for COVID-19 in Belgium by the Belgian Public Health Department (Sciensano)

MeSH Terms

Conditions

Sarcopenia; COVID-19

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof Dr Murielle Surquin MD PhD

Study Record Dates

• First Submitted: February 23, 2021
• First Posted: February 26, 2021
• Study Start: September 1, 2020
• Primary Completion: August 20, 2021
• Study Completion: August 20, 2021
• Last Updated: April 6, 2022

Record last verified: 2022-03

Locations

BE (1)