Auditory Processes and Emotional Perception in Schizophrenia

NCT04768335 | Unknown

• 1 other identifier: CSRM01
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Schizophrenia is a mental illness with a variety of clinical symptoms that can be regrouped into 2 categories: positive and negative symptoms. This mental illness is also characterised by cognitive alterations in various fields, including social cognition difficulties and self / non-self-discrimination difficulties. Self and non-self-discrimination abilities have been regrouped under a function called source memory. This source memory enables a person to identify the source of an information previously encoded. In our everyday life, these processes are necessary to distinguish events generated by an external source from imagined events. It is called reality monitoring. A number of studies have evidenced reality-monitoring alterations in patients suffering from schizophrenia. More specifically, patients would present with an externalisation bias, they would assign more imagined events to an external source. The knowledge of these deficits encourages the study of the processes involved in order to better understand the alterations, particularly including auditory processes. A recent study has shown that discrimination errors concerning certain sound characteristics (e.g. frequency) were associated to reality monitoring errors. However, the links between reality-monitoring and basic auditory processes have rarely been explored. The dysfunction of the auditory "where" path, especially the possibility to discriminate between the intra and extra cephalic localisation of sounds, could lead to difficulties to discern between what is produced by one self and what is produced by another or the local environment.

Conditions

Basic Auditory Processes; Emotional Perception; Source Monitoring Deficits

Keywords

auditory processes; emotional perception; source monitoring; schizophrenia

Outcome Measures

Primary Outcomes (1)

• Performance on a Reality monitoring task and on an externalization task

  A computerized source memory task was designed for this study and a computerized externalization task was also designed (see description above). Rate of correct responses in both tasks is the main outcome.

  one day

Secondary Outcomes (3)

• Performance on a task measuring the impact of emotional stimuli on externalization processes

  one day

• Performance on source separating paradigms

  one day

• Performance on basic auditory tasks

  one day

Study Arms (2)

Patient group with schizophrenia

ACTIVE COMPARATOR

The schizophrenic subjects will undertake a 3 hour session of cognitive experiments. Tasks will include a battery of psychoacoustic tests, a source monitoring task, an externalization task, a pitch discrimination task and a speech-in-speech task.

Behavioral: cognitive experiments' session

Healthy control subjects

ACTIVE COMPARATOR

Healthy control subjects will undertake a 3 hour session of cognitive experiments. Tasks will include a battery of psychoacoustic tests, a source monitoring task, an externalization task, a pitch discrimination task and a speech-in-speech task.

Behavioral: cognitive experiments' session

Interventions

cognitive experiments' session BEHAVIORAL

The aim of this unique session of cognitive experiments is to study the links between source memory deficits and externalization abilities in healthy control subjects. Results of this Arm 2 will be compared to those of Arm 1.

Healthy control subjects; Patient group with schizophrenia

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Subjects aged between 18 and 65 years old - written given consent
• For patients with schizophrenia:
• \- that meet the DSM-5.0 schizophrenia criteria
• For healthy control subjects:
• absence of psychiatric disroders (past and actual) diagnosed according to the DSM-5.0
• absence of prodromal psychosis as measured by a score under 6 at the Prodromal Questionnaire PQ-16 (Ising et al., 2012)
• absence of auditory disorders (actual and past) (including tinnitus)
• absence of medical treatment (to the exception of contraceptive pills

You may not qualify if:

• history of neurological disorders or brain injury with loss of consciousness
• subjects presenting with highly developed musical abilities (frequently practicing a musical instrument)
• subjects presenting with an intellectual deficiency as measured by the Raven progressive matrices
• subjects under guardianship

Sponsors & Collaborators

• Hôpital le Vinatier: lead

Study Sites (1)

Centre Hospitalier le Vinatier

Bron, 69678, France

RECRUITING

MeSH Terms

Conditions

Schizophrenia

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Central Study Contacts

Lydie SARTELET

CONTACT

0437915531; lydie.sartelet@ch-le-vinatier.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 9, 2021
• First Posted: February 24, 2021
• Study Start: March 31, 2021
• Primary Completion: September 1, 2023
• Study Completion: September 1, 2024
• Last Updated: March 24, 2022

Record last verified: 2022-03

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)