Observing the Perioperative Effects of Prehabilitation in Colorectal Cancer Patients

NCT04762914 | Completed

• 1 other identifier: 2021.038N
• Study Type: observational
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

Quality Improvement Project to evaluate how prehabilitation can be incorporated into our colorectal cancer pathway and assess its clinical benefits.

Conditions

Colon Cancer

Keywords

Prehabilitation

Outcome Measures

Primary Outcomes (2)

• Length of stay

  Time spent in hospital

  From date of operation to date of discharge in number of days over a 90 day follow up period

• Complication rate

  All Clavien-Dindo complications

  Follow up over a period of 90 days following operation

Secondary Outcomes (1)

• Anaerobic threshold

  CPET performed before prehabilitation and after prehabilitation (median of 36 days)

Study Arms (2)

Prehabilitation (PH)

Patients who underwent prehabilitation prior to colorectal cancer resection

Other: Prehabilitation

Non-Prehabilitation (NPH)

Patients who did not undergo prehabilitation prior to colorectal cancer resection

Interventions

Prehabilitation OTHER

Prehabilitation is a multimodal and multidisciplinary person-centred perioperative approach involving supervised exercise training, nutritional education, management of polypharmacy and psychological advice.

Prehabilitation (PH)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Consecutive patients over the age of 18 needing surgery were identified from clinics, endoscopy or weekly multidisciplinary meetings (MDT). Patients who were clinically judged to be frail or had multiple comorbidities were referred for prehabilitation prior to resection. Those that underwent prehabilitation were matched using operation type, age, sex and ASA with patients who did not have prehabilitation prior to resection. Surgery for all patients was carried out within the context of an enhanced recovery programme.

You may qualify if:

• Adults over the age of 18 who had prehabilitation for colorectal cancer

You may not qualify if:

• Children
• Patients who had prehabilitation but not for colorectal cancer

Sponsors & Collaborators

• Medway Primary Care Trust: lead

Study Sites (1)

Medway Hospitals NHS Trust

Gillingham, Kent, ME7 5NY, United Kingdom

Location

MeSH Terms

Conditions

Colonic Neoplasms

Interventions

Preoperative Exercise

Condition Hierarchy (Ancestors)

Colorectal Neoplasms; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases

Intervention Hierarchy (Ancestors)

Perioperative Care; Patient Care; Therapeutics; Surgical Procedures, Operative; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Health Services; Health Care Facilities Workforce and Services

Study Officials

• Richard A Dickson-Lowe

  Medway PCT

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Consultant Surgeon

Study Record Dates

• First Submitted: January 22, 2021
• First Posted: February 21, 2021
• Study Start: September 1, 2018
• Primary Completion: December 31, 2019
• Study Completion: December 31, 2019
• Last Updated: February 21, 2021

Record last verified: 2021-02

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)