NCT04761497

Brief Summary

The purpose of this study is to determine what type of music therapy (active versus passive) approach has higher effects on clinical symptoms in advanced Alzheimer's disease patients

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
90

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Sep 2018

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 12, 2018

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 19, 2018

Completed
19 days until next milestone

Study Completion

Last participant's last visit for all outcomes

January 7, 2019

Completed
2.1 years until next milestone

First Submitted

Initial submission to the registry

February 12, 2021

Completed
9 days until next milestone

First Posted

Study publicly available on registry

February 21, 2021

Completed
Last Updated

February 21, 2021

Status Verified

February 1, 2021

Enrollment Period

3 months

First QC Date

February 12, 2021

Last Update Submit

February 17, 2021

Conditions

Keywords

Alzheimer's diseasecognition.behaviourfunctionmotor functionactive music therapypassive music therapy

Outcome Measures

Primary Outcomes (5)

  • Mini Examination of the Mental State

    Cognitive status. Range 0-30. Higher scores indicate better cognition

    0-3 months

  • Neuropsychiatric Inventory

    Behavioural disorders. Range 0-144. Higher scores indicate greater behavioural problems

    0-3 months

  • Geriatric depression scale

    Mood status. Range 0-15. Higher scores indicate worse mood status

    0-3 months

  • Barthel index

    Functional status. Range 0-100.Higher scores indicate worse functional status

    0-3 months

  • Tinneti scale.Higher scores indicate better motor function

    Motor function

    0-3 months. Range 0-28

Study Arms (3)

active music therapy

EXPERIMENTAL

Each session consisted of: song of welcome (patients had to greet and introduce themselves), rhythmic exercise (three songs were used; therapist and patients kept rhythm by clapping their hands), dance exercises (three songs were used; patients should make free body movements in response to music), game of recognition of songs and interpreters (four songs were used) and song of goodbye.

Other: Actice music therapy

passive music therapy

EXPERIMENTAL

The therapist and the patients were seat listening to the music recorded in a CD. The therapist told patients which the name and the interpreter of each song of the list.

Other: Passive music therapy

control

PLACEBO COMPARATOR

Patients were watching nature videos for the same duration than the interventions. A therapist was with them facilitating the activity.

Other: Watching nature videos

Interventions

active music therapy sessions for three months

active music therapy

nature videos sessions for three months

control

passive music therapy for three months

passive music therapy

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Nursing-home dwelling
  • Diagnosis of probable Alzheimer's disease
  • Mild or moderate stage (Clinical Classification of the Dementia)

You may not qualify if:

  • Aphasia
  • Hearing impairment that may affect participation in the activities.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

UCMurcia

Murcia, 30107, Spain

Location

MeSH Terms

Conditions

Alzheimer DiseaseBehavior

Condition Hierarchy (Ancestors)

DementiaBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesTauopathiesNeurodegenerative DiseasesNeurocognitive DisordersMental Disorders

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Profª Dr María Gómez-Gallego

Study Record Dates

First Submitted

February 12, 2021

First Posted

February 21, 2021

Study Start

September 12, 2018

Primary Completion

December 19, 2018

Study Completion

January 7, 2019

Last Updated

February 21, 2021

Record last verified: 2021-02

Data Sharing

IPD Sharing
Will not share

Locations