The Value of Central Venous-arterial Carbon Dioxide Difference

NCT04761237 | Completed

• 1 other identifier: 2015-047-01
• Study Type: interventional
• Target: 118
• Locations: 0 countries
• Sites: N/A

Brief Summary

By observing the changes of Central venous-arterial partial pressure difference of carbon dioxide \[P (v-a) CO2\] in liquid resuscitation during early escharectomy in patients with large-scale burns, We investigate the effect of P (v-a) CO2 on postoperative tissue perfusion and oxygenation in order to seek a more effective intergrated target plan of liquid resuscitation for burn patients.

Conditions

Jugular Veins; Radial Artery; Carbon Dioxide

Keywords

central venous-arterial carbon dioxide difference; liquid resuscitation; tissue perfusion and oxygenation

Outcome Measures

Primary Outcomes (2)

• Central venous oxygen saturation

  Central venous oxygen saturation in venous blood

  From start anesthesia until end of anesthesia, up to a maximum of 6 hours

• Lactic acid value

  Lactic acid level in arterial blood

  From start anesthesia until end of anesthesia, up to a maximum of 6 hours

Study Arms (2)

Group 1

EXPERIMENTAL

(H-P) : Pcv-aCO2≥6mmHg between T base and T 0h.;

Drug: Goal-directed fluid therapy (GDET)

Group 2

EXPERIMENTAL

(L-P) : Pcv-aco2\< 6mmHg at T base and≥6mmHg at T 0h

Drug: Goal-directed fluid therapy (GDET)

Interventions

Goal-directed fluid therapy (GDET) DRUG

Compensatory dilatation was performed firstly and 5ml/kg crystal solution was added within 30min before induction of anesthesia.When SVV≥13%, infusion of colloidal solution 2ml/kg was performed 15-20 minutes.If the increase of SV was≥10% after the liquid impact and the SVV was still≥13%, the colloidal solution was used again for 2mL/kg and the infusion was maintained until the SVV \< 13%.The infusion was stopped when the SVV \< 10%.If the increase of SV was less than 10% or CI \< 2.0L/min/m2 after infusion, dobutamine was given intravenously to observe the change of SV. If the increase of SV was greater than 10%, dobutamine could be maintained and the above fluid regimen continued.If the increase of SV was less than 10% and MAP≥65mmHg, the infusion of liquid was stopped and replaced with 4ml/kg/h infusion for maintenance.If the increase of SV was less than 10% and MAP was less than 65mmHg, the infusion was suspended.

Group 1; Group 2

Eligibility Criteria

• Age: 20 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ASAI-II
• New York Heart Association classification of cardiac function I-II
• Estimated time of operation\<3h
• The circulatory system of patients is stable after thrapy：CVP8～12 mmHg；MAP≥65 mmHg；urine volume\>0.5m1/kg/ h；ScvO2：≥70％。

You may not qualify if:

• Anesthetic drug allergy or contraindication
• Patients with cardiopulmonary system disease、cardiopulmonary function abnormality、severe inhalation injuryand severe visceral injury.

Sponsors & Collaborators

• Liang Bing: lead

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Participants are prevented from having knowledge of the interventions assigned to individual participants.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate chief physician

Study Record Dates

• First Submitted: January 19, 2021
• First Posted: February 18, 2021
• Study Start: January 1, 2017
• Primary Completion: December 30, 2019
• Study Completion: December 30, 2019
• Last Updated: February 18, 2021

Record last verified: 2021-02