Analysis of Motor Skills in Subjects Aged 55 and Over: the Role of Cognitive Abilities for Planning Movement.

NCT04754906 | Recruiting

• 1 other identifier: MANCKOUNDIA 2018
• Study Type: observational
• Target: 684
• Locations: 1 country
• Sites: 1

Brief Summary

Falling is an event that is more frequent and severe in older age. It can lead to a loss of autonomy and a decrease in quality of life. It is therefore important to understand this phenomenon in order to better prevent it. Among the multiple risk factors associated with falling, recent research has shown a link between the decline in cognitive abilities (i.e., the mental processes that form our knowledge, such as memory) and the risk of falling. However, the impact of this cognitive decline on motor skills is still poorly understood. The purpose of this research is to study how the changes induced by aging affect motor skills. This would make it possible to take a new look at the phenomenon of falls occurring in the elderly and, in the long term, to improve the prevention and rehabilitation.

Conditions

Mild Cognitive Disorder

Outcome Measures

Primary Outcomes (3)

• Sequence 1: symmetry ratio of the finger speed profile

  through study completion, an average of 3 years

• Sequence 2 : perception bias (error in degrees of angle) of dynamic subjective visual vericality

  through study completion, an average of 3 years

• Sequence 3 : activation time of the focal muscles in relation to the postural muscles

  through study completion, an average of 3 years

Study Arms (3)

young neurotypical subjects

people from 18 to 40 years old

Other: Sequence 1; Other: Sequence 2; Other: Sequence 3

elderly neurotypical subjects

people over 55 years of age

Other: Sequence 1; Other: Sequence 2; Other: Sequence 3

Elderly subjects with mild cognitive impairment

people over 55 years of age, with a diagnosis of mild cognitive impairment

Other: Sequence 1; Other: Sequence 2; Other: Sequence 3

Interventions

Sequence 1 OTHER

perform arm movements towards a target

Elderly subjects with mild cognitive impairment; elderly neurotypical subjects; young neurotypical subjects

Sequence 2 OTHER

judge the verticality of an object

Elderly subjects with mild cognitive impairment; elderly neurotypical subjects; young neurotypical subjects

Sequence 3 OTHER

In standing position, point as quickly as possible with the right arm at the diode that will light up in front of the participant.

Elderly subjects with mild cognitive impairment; elderly neurotypical subjects; young neurotypical subjects

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

young subjects, elderly neurotypical subjects and elderly subjects with mild cognitive disorder

You may qualify if:

• Neurotypical subjects group:
• Person aged 18 to 40 years
• Person who has given oral consent
• Affiliated to national health insurance
• Right-handed person
• Group of elderly neurotypical subjects:
• Person over 55 years of age
• Person who has given oral consent
• Affiliated to national health insurance
• No cognitive problems (MMSE score \>26)
• Right-handed person
• Elderly mild cognitive disorder subject group:
• Person over 55 years of age
• Person who has given oral consent
• Diagnosis of Mild Cognitive Disorder made by a neurologist at the Centre Mémoire Ressources et Recherche (CMRR) of the University Hospital of Dijon, following the recommendations of the National Institute for Aging and Alzheimer's Association (Albert et al., 2011) This diagnosis is based on psychometric tests, brain imaging and the evolution of cognitive disorders, including an MMSE test.

You may not qualify if:

• Neurological or psychiatric history with the exception of the TCL group.
• Follow-up of drug treatment in the last three months that may affect cognitive and/or motor skills.
• Received a shoulder prosthesis on the dominant side.
• Received a hip and/or knee replacement less than a year ago.
• Disabling joint disease of the hip or knee shoulder
• Protected adults (curatorship, guardianship)
• Person deprived of their liberty b judicial or administrative decision
• Pregnant, parturient or breastfeeding woman
• Major unable to consent

Sponsors & Collaborators

• Centre Hospitalier Universitaire Dijon: lead

Study Sites (1)

Chu Dijon Bourgogne

Dijon, 21000, France

RECRUITING

MeSH Terms

Conditions

Neurocognitive Disorders

Condition Hierarchy (Ancestors)

Mental Disorders

Central Study Contacts

Patrick MANCKOUNDIA

CONTACT

0380293970; patrick.manckoundia@chu-dijon.fr

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 6, 2020
• First Posted: February 15, 2021
• Study Start: January 25, 2021
• Primary Completion (Estimated): December 1, 2028
• Study Completion (Estimated): December 1, 2028
• Last Updated: September 22, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)