Evaluation of Adult Onset Still Disease Classification Criteria and Differential Diagnosis at Eighteen Months of Follow-up

NCT04750863 | Completed

• 1 other identifier: 2021PI001
• Study Type: observational
• Target: 312
• Locations: 0 countries
• Sites: N/A

Brief Summary

Adult Onset Still Disease (AOSD) is an acquired inflammatory disease of unknown etiology, presenting with non specific symptoms. Its diagnosis rely on sets of criteria, i.e. Fautrel Criteria and Yamaguchi Criteria. However, differential diagnosis might appear during follow-up of patients. The aim of this study is to assess diagnostic performance of Fautral and Yamaguchi Criteria after 18 months of follow-up, and to describe differential diagnosis appearing during follow-up.

Conditions

Adult Onset Still Disease

Keywords

adult onset still disease; differential diagnosis; diagnosis performance

Outcome Measures

Primary Outcomes (1)

• diagnosis performance of Yamaguchi and Fautrel criteria at 18 months of follow-up

  Sensitivity, Specificity, positive predictive value, negative predictive value

  after 18 months of follow-up

Secondary Outcomes (2)

• description of differential diagnosis mimicking adult onset still disease

  after 18 months of follow-up

• identifying factors associated with the occurence of a differential diagnosis during follow-up

  after 18 months of follow-up

Interventions

diagnosis criteria performance OTHER

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients with suspected adult onset still disease with at least 18 months of follow-up.

You may qualify if:

• adults
• with glycosylated ferritin dosage for suspected adult onset still disease
• with at least 18 month of follow-up

You may not qualify if:

• known infectious disease
• known cancer
• known active connective tissue disease or vasculitis

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

MeSH Terms

Conditions

Still's Disease, Adult-Onset

Condition Hierarchy (Ancestors)

Arthritis, Rheumatoid; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 8, 2021
• First Posted: February 11, 2021
• Study Start: July 15, 2010
• Primary Completion: February 1, 2021
• Study Completion: February 1, 2021
• Last Updated: February 11, 2021

Record last verified: 2021-02

Data Sharing

• IPD Sharing: Will not share