Global IBD Visualization of Epidemiology Studies (GIVES) in the 21st Century
GIVES-21
1 other identifier
observational
400
1 country
1
Brief Summary
Crohn's disease (CD) and Ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBD) of unknown etiology. The pathophysiology of IBD relates to the mucosal immune response to antigenic stimulation from the gut microbiota secondary to environmental influence, on a background of genetic susceptibility. IBD represents an important public health problem because it affects mostly young people at an age when they are most active in their private and professional life, and a management challenge because of its unpredictable relapsing nature. During the last few decades the incidence of IBD has changed in many ways. Incidence rates of traditionally high incidence areas such as the United States and Europe is remaining relatively stable or even decreasing, while the diseases have become more prevalent in previously low incidence areas, including Asia. Our latest systematic review has demonstrated that the highest reported prevalence of IBD was still in Europe and North America, however, the incidence of IBD has been rising in newly industrialized countries since 1990.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Oct 2021
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 9, 2021
CompletedFirst Posted
Study publicly available on registry
February 10, 2021
CompletedStudy Start
First participant enrolled
October 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2023
CompletedDecember 5, 2023
November 1, 2023
2.2 years
February 9, 2021
November 29, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
Incidence of IBD
To determine the incidence of IBD in 19 regions globally, and to investigate if this increase is caused by environmental and dietary factors.
1 year
Secondary Outcomes (1)
Geographical effect
1 year
Eligibility Criteria
For IBD patients: Newly diagnosed IBD patients in the local area For heathy control: Asymptomatic adults who have no IBD or any other chronic medical illnesses.
You may qualify if:
- Aged ≥ 18 years old
- Confirmed diagnosis of Crohn's disease or Ulcerative Colitis according to established clinical, endoscopic and histological criteria
- Written informed consent obtained
You may not qualify if:
- Nil
- For healthy control:
- Aged ≥ 18 years old
- Asymptomatic
- Written informed consent obtained
- Diagnosis of any chronic medical illnesses.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Chinese University of Hong Konglead
- University of Calgarycollaborator
Study Sites (1)
Prince of Wales Hospital
Hong Kong, Hong Kong
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Siew Chien Ng, PhD
Chinese University of Hong Kong
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
February 9, 2021
First Posted
February 10, 2021
Study Start
October 1, 2021
Primary Completion
December 1, 2023
Study Completion
December 1, 2023
Last Updated
December 5, 2023
Record last verified: 2023-11