Quantification of Abdominal Organ Motion Using MRI

NCT04748094 | Completed

• 1 other identifier: CFTSp166
• Study Type: observational
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

The primary aim of the study is to quantify abdominal motion in order to optimise MR imaging. The study will compare three-motion management strategies a) free-breathing, b) using an abdominal compression belt and c) using MRI-compatible visually guided breath-holds.

Conditions

Cancer

Keywords

MRI

Outcome Measures

Primary Outcomes (1)

• MRI Motion Management SOP

  Development and implementation of an MRI protocol suitable for organ motion characterisation for the abdomen. Determination of the benefit of motion management strategies for abdominal radiotherapy.

  through study completion, approximately 6 months

Secondary Outcomes (1)

• Quantification of motion

  through study completion, approximately 6 months

Study Arms (2)

Free-breathing versus Compression

This cohort of volunteers and patients will undergo imaging on the MR-Linac investigating free-breathing motion, and comparing it to motion using an abdominal compression device.

Device: Compression belt

Free-breathing versus Breath-holding

This cohort of volunteers and patients will undergo imaging on the MRSim investigating free-breathing motion and comparing it to visually-guided breath-hold motion (and reproducibility).

Other: Visual Guided Breath-hold

Interventions

Compression belt DEVICE

The abdominal belt is fastened around the lower abdomen and inflated (like an inner tube) to apply pressure to the belly and reduce the motion associated with respiration (breathing)

Free-breathing versus Compression

Visual Guided Breath-hold OTHER

A small tracer will be place on the lower abdomen that will feedback to a computer screen that will have graphics to show you if the participant is in breath-hold or not.

Free-breathing versus Breath-holding

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients or staff at The Christie NHS Foundation Trust

You may qualify if:

• Healthy volunteers
• years or older,
• no MRI contra-indications
• must agree to registration as a non-patient in CWP (the local electronic healthcare records system) and have their MRIs read and reviewed for incidental findings by a clinical radiologist
• Patient Volunteers
• undergoing radiotherapy to the abdominal region at the Christie NHS Foundation Trust
• Over 18 years of age

You may not qualify if:

• Any contraindications to MRI identified after MRI safety screening including completion of an MRI Safety Screening Form
• Unable to tolerate MRI scan
• Pregnancy
• Colostomy

Sponsors & Collaborators

• The Christie NHS Foundation Trust: lead

Study Sites (1)

The Christie NHS Foundation Trust

Manchester, Greater Manchester, M20 4BX, United Kingdom

Location

MeSH Terms

Conditions

Neoplasms

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 27, 2021
• First Posted: February 10, 2021
• Study Start: May 21, 2021
• Primary Completion: March 15, 2023
• Study Completion: March 15, 2023
• Last Updated: August 27, 2025

Record last verified: 2025-08

Locations

GB (1)