NCT04747886

Brief Summary

The purpose of this pilot study is to explore the benefits of supplementing the WW (formerly Weight Watchers) online program with a cognitive training game (PolyRules!) among adults with overweight or obesity.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
34

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Mar 2021

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 25, 2021

Completed
16 days until next milestone

First Posted

Study publicly available on registry

February 10, 2021

Completed
1 month until next milestone

Study Start

First participant enrolled

March 12, 2021

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 31, 2021

Completed
10 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 4, 2022

Completed
2.2 years until next milestone

Results Posted

Study results publicly available

August 29, 2024

Completed
Last Updated

August 29, 2024

Status Verified

August 1, 2024

Enrollment Period

5 months

First QC Date

January 25, 2021

Results QC Date

June 15, 2022

Last Update Submit

August 26, 2024

Conditions

Outcome Measures

Primary Outcomes (1)

  • BMI at Three Months

    BMI will be calculated by aggregating participants' self-reported height in meters and weight in kilograms at baseline and at 3 months. Throughout the study, participants will be asked to self-report their weight through the WW (formerly Weight Watchers) online app. This data will be used to calculate change in BMI.

    Baseline, 3 months

Other Outcomes (7)

  • Change in Visuo-spatial Working Memory Based on Performance on the Corsi Task.

    Baseline, 3 months

  • Change in Performance on the Letter-number Task.

    Baseline, 3 months

  • Change in Performance on the N-back Task.

    Baseline, 3 months

  • +4 more other outcomes

Study Arms (2)

WW Only

ACTIVE COMPARATOR

Participants will receive 3-month access to the WW digital program.

Behavioral: WW Only

WW + PolyRules!

EXPERIMENTAL

Participants will receive 3-month access to the WW digital program and the PolyRules! app.

Behavioral: WW + PolyRules!

Interventions

WW OnlyBEHAVIORAL

WW is a structured behavioral weight management program that focuses on diet, physical activity and mindset skills. The dietary approach is based on creating an energy deficit diet to produce weight loss while also being attentive to the quality of the calories. Specifically, the WW program assigns SmartPoints values to foods based on calories, sugar, saturated fat and protein. In addition, particular foods are assigned a points value of zero (0) to encourage a healthier eating pattern (e.g. fruits, vegetables, non-fat yogurt, fish).

WW Only
WW + PolyRules!BEHAVIORAL

In addition to WW, participants will be asked to engage in daily cognitive training using the PolyRules! app for three months. They will be instructed to start with 20-min of daily cognitive training and to progressively increase their training time to 30-min.

WW + PolyRules!

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • years of age or older
  • Read, write and speak English with acceptable visual acuity
  • BMI between 25-40 kg/m\^2

You may not qualify if:

  • Currently enrolled in weight loss interventions or undergoing bariatric surgery
  • Pregnant women
  • Individuals with severe cognitive delays or visual/hearing impairment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Pacific Design Center

West Hollywood, California, 90069, United States

Location

MeSH Terms

Conditions

OverweightObesity

Condition Hierarchy (Ancestors)

OvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Limitations and Caveats

1. Small and homogeneous sample of participants. Individuals who took part in the study were highly educated, affluent and 86.7% were women. 2. Short intervention duration compared to other weight management trials. 3. Reliance on self-report.

Results Point of Contact

Title
Dr. Sarah-Jeanne Salvy
Organization
Cedars-Sinai Medical Center

Study Officials

  • Sarah-Jeanne Salvy, PhD

    Cedars-Sinai Medical Center

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor, Department of Medicine

Study Record Dates

First Submitted

January 25, 2021

First Posted

February 10, 2021

Study Start

March 12, 2021

Primary Completion

July 31, 2021

Study Completion

June 4, 2022

Last Updated

August 29, 2024

Results First Posted

August 29, 2024

Record last verified: 2024-08

Data Sharing

IPD Sharing
Will not share

Locations