NCT04744818|CompletedDMC
Effects of Iron Supplementation on Pediatric Vaccine Response
VINO
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VINO
Sponsor study identifier
interventional
288
2 countries
2
Study Start
February 7, 2021
Actual (reported)Primary Completion
April 3, 2023
Actual (reported)Study Completion
October 16, 2023
Actual (reported)ID/IDA affects many young children in Africa. Vaccines provide tremendous benefits in LMIC; however, they currently fail to reach their full potential. We need to better understand the causes of vaccine failure, in order to develop new strategies to improve vaccine immunogenicity. This study will contribute to children's health by: (1) providing updated guidelines to better define the prevalence of ID/IDA in early infancy, and its safe and effective control using iron; and (2) providing a new approach to improve response to pediatric vaccines in LMIC, by ensuring adequate iron status at time of vaccination.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 16, 2023
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 28, 2021
Actual (reported)February 7, 2021
Actual (reported)February 9, 2021
Actual (reported)April 3, 2023
Actual (reported)October 16, 2023
Actual (reported)Pertussis antibody profile
from 6 to 24 weeks
Diphtheria antibody profile
from 6 to 24 weeks
antiviral immunoglobulin G response
6 weeks of age
antiviral immunoglobulin G response
24 weeks of age
infant antiviral immunoglobulin G response
52 weeks of age
immune cell populations
6 weeks of age
immune cell populations
24 weeks of age
Human milk oligosaccharide secretor type
14 weeks of age
Erythrocyte zinc protoporphyrin
6 weeks of age
Erythrocyte zinc protoporphyrin
14 weeks of age
Iron and multivitamin syrup
Multivitamin syrup
Daily supplementation with iron
Daily supplementation with multivitamins
Msambweni County Referral Hospital
Msambweni, Kwale County, Kenya
Human Nutrition Laboratory ETH Zurich
Zurich, 8092, Switzerland
288 participants (actual enrollment reported by the registry).
First Submitted
January 28, 2021
First Posted
February 9, 2021
Study Start
February 7, 2021
Actual (reported)Evaluation of the Effects of Routine Iron Supplementation in Children on Gastrointestinal Iron Losses
Iron Bioavailability From Biofortified Orange-fleshed Sweet Potato
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
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Primary Completion
April 3, 2023
Actual (reported)Study Completion
October 16, 2023
Actual (reported)Last Updated
January 24, 2024
Record last verified: 2024-01
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Source: ClinicalTrials.gov.
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