NCT04744415

Brief Summary

Multicentre, national, observational, retrospective and prospective study. The BLITZ-COVID19 study aims at describing the epidemiology of admissions to Italian Cardiology Intensive Care Units in the COVID-19 infection pandemia, the main aspects of the clinical management of inpatients, their short-term outcome, the absorption of resources related to their admission.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
6,054

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Nov 2020

Shorter than P25 for all trials

Geographic Reach
1 country

109 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 9, 2020

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

February 2, 2021

Completed
7 days until next milestone

First Posted

Study publicly available on registry

February 9, 2021

Completed
Same day until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 9, 2021

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

March 23, 2021

Completed
Last Updated

January 2, 2026

Status Verified

December 1, 2025

Enrollment Period

3 months

First QC Date

February 2, 2021

Last Update Submit

December 29, 2025

Conditions

Outcome Measures

Primary Outcomes (3)

  • Impact that COVID-19 infection may have had on the in-hospital mortality

    Impact that COVID-19 infection may have had on the in-hospital mortality of the various clinical conditions admitted to ICU

    Enrollment

  • Epidemiology and management of patients admitted to ICU

    The different diagnoses of discharge from the ICU and their frequency will be described. All hospitalized cardiac and non-cardiac pathologies will be listed, with particular reference to any COVID-19 infection.

    Enrollment

  • Management of patients admitted to ICU

    Description of the main therapeutic decision in patients hospitalized for the most relevant pathologies

    Enrollment

Interventions

Cardiology Intensive Care Unit admission

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

All patients aged ≥18 years admitted with any diagnoses to ICU in the specified periods of 30 days each. Retrospecitve phase:(March 1-30, 2020 in the Northern or Centre-North regions; March 15-April 13, 2020 in the Southern or Ventre\_South Regions and island. Perspective phase (depending by the IRB approval) in the following periods: November 9-December 8, 2020; November 23-December 22, 2020; January 11-February 9, 2021. (Retrospective study) or in the

You may qualify if:

  • \- All patients aged ≥18 years admitted with any diagnosis to one of the participating ICU

You may not qualify if:

  • \- Refuse to signe consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (109)

Ospedale Santo Spirito - Sc Cardiologia

Casale Monferrato, AL, Italy

Location

Istituto Scientifico Inrca - Uo Cardiologia/Utic/Telecardiologia

Ancona, AN, Italy

Location

Ospedale Generale Regionale-Po U. Parini - U.O. Cardiologia E Cure Intensive Card.

Aosta, AO, Italy

Location

Po Sant'Ottone Frangipane - U.O.C. Cardiologia - Utic

Ariano Irpino, AV, Italy

Location

Aorn San Giuseppe Moscati - U.O. Cardiologia/Utic 'D. Rotiroti'

Avellino, AV, Italy

Location

Ospedale Miulli - U.O.C. Cardiologia - Utic

Acquaviva delle Fonti, BA, Italy

Location

Aou Policlinico - Uoc Cardiologia Ospedaliera

Bari, BA, Italy

Location

Ospedale Di Venere - U.O.C. Di Cardiologia

Bari, BA, Italy

Location

Ospedale San Paolo - Cardiologia-Utic

Bari, BA, Italy

Location

Ospedale Di Bentivoglio - U.O. Di Cardiologia

Bentivoglio, BO, Italy

Location

Ospedale Maggiore - U.O. Di Cardiologia

Bologna, BO, Italy

Location

Asst Spedali Civili - Cardiologia

Brescia, BS, Italy

Location

Ospedale Generale Regionale - Divisione Di Cardiologia

Bolzano, BZ, Italy

Location

Arnas G. Brotzu - Cardiologia Con Utic

Cagliari, CA, Italy

Location

A.O.U. Cagliari Policlinico Monserrato - Sc Cardiologia Utic Emodinamica

Monserrato, CA, Italy

Location

Ospedale A. Cardarelli - U.O. Cardiologia E Utic

Campobasso, CB, Italy

Location

Presidio Ospedaliero Moscati - U.O.C. Cardiologia-Utic

Aversa, CE, Italy

Location

Az. Ospedaliera S. Anna E S. Sebastiano - U.O. Cardiologia-Utic

Caserta, CE, Italy

Location

Ospedale San Giuseppe E Melorio - U.O.C. Cardiologia Utic

Santa Maria Capua Vetere, CE, Italy

Location

Presidio Ospedaliero San Rocco - U.O.C. Cardiologia - Utic

Sessa Aurunca, CE, Italy

Location

Ospedale San Pio Da Pietrelcina - Cardiologia

Vasto, CH, Italy

Location

Ospedale Regina Montis Regalis - U.O. Cardiologia-Utic

Mondovì, CN, Italy

Location

Ospedale Maggiore Ss. Annunziata - Sc Cardiologia

Savigliano, CN, Italy

Location

Ospedale Moriggia Pelascini - Unita' Operativa Di Cardiologia

Gravedona, CO, Italy

Location

Ospedale S. Anna - U.O.C. Di Cardiologia

San Fermo della Battaglia, CO, Italy

Location

P.O. Garibaldi Centro - U.O.C. Cardiologia

Catania, CT, Italy

Location

Centro Cuore Morgagni - U.F. Utic Ed Emodinamica

Pedara, CT, Italy

Location

Arcispedale Sant'Anna - U.O. Cardiologia - Utic

Ferrara, FE, Italy

Location

Ospedali Riuniti - S.C. Di Cardiologia Univ.-Utic

Foggia, FG, Italy

Location

Ospedale Casa Sollievo Della Sofferenza - Cardiologia - Utic - Riabil Cardiologica

San Giovanni Rotondo, FG, Italy

Location

Ospedale Santa Maria Annunziata - Cardiologia

Bagno a Ripoli, FI, Italy

Location

Ospedale San Giuseppe - Cardiologia

Empoli, FI, Italy

Location

Aou Careggi - Cardiologia Interventistica

Florence, FI, Italy

Location

Ospedale San Giovanni Di Dio - Cardiologia

Florence, FI, Italy

Location

Ospedale Santa Maria Nuova - Hdu Cardiologica/Utic

Florence, FI, Italy

Location

E.O. Ospedali Galliera - S. C. Cardiologia

Genova, GE, Italy

Location

Presidio Ospedaliero - U.O. Cardiologia

Sanremo, IM, Italy

Location

Ospedale Civile Sacro Cuore Di Gesu' - Uo Cardiologia Utic

Gallipoli, LE, Italy

Location

Ospedale Ignazio Veris Delli Ponti - Uoc Cardiologia-Utic

Scorrano, LE, Italy

Location

Azienda Osp. Cardinale G. Panico - U.O. Cardiologia - Utic

Tricase, LE, Italy

Location

Ospedali Riuniti - U.O.C. Cardiologia E Utic

Livorno, LI, Italy

Location

Nuovo Ospedale Versilia - Sc Cardiologia

Lido di Camaiore, LU, Italy

Location

Ospedale San Gerardo - U.O. Cardiologia-Utic

Monza, MB, Italy

Location

Aor Papardo - U.O. Cardiologia Con Utic

Messina, ME, Italy

Location

Ospedale Piemonte - Cardiologia E Utic

Messina, ME, Italy

Location

Centro Cardiologico Monzino - Terapia Intensiva Cardiologica (Utic)

Milan, MI, Italy

Location

Irccs Policlinico Multimedica - Uo Di Cardiologia

Sesto San Giovanni, MI, Italy

Location

Ospedale Civile Di Baggiovara - U.O. Di Cardiologia

Modena, MO, Italy

Location

Aou Maggiore Della Carita' - Cardiologia Ii

Novara, NOVARA, Italy

Location

Ospedale San Francesco - Cardiologia - Utic

Nuoro, NU, Italy

Location

Fondazione G. Giglio - U.O. Cardiologia E Utic

CefalĂ¹, PA, Italy

Location

Aor Villa Sofia-Cervello P.O. Cervello - U.O. Cardiologia - Cervello

Palermo, PA, Italy

Location

Aor Villa Sofia-Cervello Po Villa Sofia - U.O.C. Cardiologia E Utic - Villa Sofia

Palermo, PA, Italy

Location

Ospedale Civile 'Guglielmo Da Saliceto' - Uo Cardiologia

Piacenza, PC, Italy

Location

Ospedale Civile Dello Spirito Santo - Utic E Cardiologia Interventistica

Pescara, PE, Italy

Location

Presidio Ospedaliero Citta' Di Castello - U.O. Di Cardiologia

CittĂ  di Castello, PG, Italy

Location

Ospedale Gubbio-Gualdo Tadino - U.O. Di Utic E Cardiologia

Gubbio, PG, Italy

Location

Ospedale Generale Provinciale Lotti - U.O. Malattie Cardiovascolari Vde E Avc

Pontedera, PI, Italy

Location

Ospedale Di Pordenone - S.O.C. Cardiologia

Pordenone, PN, Italy

Location

Ospedale Santo Stefano - U.O. Cardiologia

Prato, PO, Italy

Location

Ospedale Ss. Cosma E Damiano - U. O. Cardiologia - Utic

Pescia, PT, Italy

Location

Ospedale Generale Di Zona - U.O. Cardiologia - Utic

Lagonegro, PZ, Italy

Location

Azienda Ospedaliera San Carlo - Ssd Utic

Potenza, PZ, Italy

Location

Ospedale Per Gli Infermi - U.O. Cardiologia - Utic

Faenza, RA, Italy

Location

Ospedale Civile Santa Maria Delle Croci - U.O. Di Cardiologia

Ravenna, RA, Italy

Location

P.O. San Camillo de Lellis - U.O.C. Cardiologia

Rieti, RI, Italy

Location

Ospedale Civile San Paolo - U.O. Cardiologia - Utic

Civitavecchia, RM, Italy

Location

Ospedale S. Maria Goretti - Uoc Malattie Cardiovascolari

Latina, RM, Italy

Location

Aurelia Hospital - U.O.C Cardiologia

Roma, RM, Italy

Location

Clinica Citta' Di Roma - Cardiologia-Utic

Roma, RM, Italy

Location

European Hospital - U.O. Cardiologia Interventistica

Roma, RM, Italy

Location

Ospedale Fatebenefratelli - U.O.C. Cardiologia

Roma, RM, Italy

Location

Ospedale San Camillo - Uoc Cardiologia

Roma, RM, Italy

Location

Ospedale Sandro Pertini - Uoc Cardiologia

Roma, RM, Italy

Location

Ospedale Sant'Andrea Di Roma - U.O.C. Cardiologia

Roma, RM, Italy

Location

PO San Filippo neri - ASL Roma1

Roma, Roma, 00135, Italy

Location

Ospedale Santa Maria Della Misericordia - U.O.C. Cardiologia

Rovigo, RO, Italy

Location

Presidio Osped. S. Maria Della Speranza - U.O. Di Cardiologia

Battipaglia, SA, Italy

Location

P.O. Nocera-Pagani - Osp. Umberto I - Uoc Cardiologia - Utic

Nocera Inferiore, SA, Italy

Location

Presidio Ospedaliero Luigi Curto - Uo Cardiologia-Utic

Polla, SA, Italy

Location

Aou S. Giovanni Di Dio-Ruggi D'Aragona - U.O.C. Utic

Salerno, SA, Italy

Location

Ospedale San Luca - U.O. Utic - Cardiologia

Vallo della Lucania, SA, Italy

Location

Ospedale Dell'Alta Val D'Elsa - Uosd Cardiologia-Utic

Poggibonsi, SI, Italy

Location

Aou Senese Ospedale S. Maria Alle Scotte - U.O.C. Cardiologia Clinico-Chirurg. Utic

Siena, SI, Italy

Location

Ospedale Civile - U.O. Cardiologia

Sondrio, SO, Italy

Location

Ospedale S. Andrea - S.C. Cardiologia

La Spezia, SP, Italy

Location

Ospedale E. Muscatello - U.O. Di Cardiologia - Utic

Augusta, SR, Italy

Location

Ospedale G. Di Maria - Cardiologia Utic

Avola, SR, Italy

Location

P.O. Lentini - U.O. Di Cardiologia Con Utic

Lentini, SR, Italy

Location

Ospedale Nostra Signora Di Bonaria - U.O.C. Cardiologia E Utic

San Gavino Monreale, SU, Italy

Location

Ospedale Santa Maria Del Carmine - Cardiologia

Rovereto, TN, Italy

Location

Ospedale Santa Chiara - Divisione Di Cardiologia

Trento, TN, Italy

Location

Po S. Antonio Abate Di Trapani - U.O.C. Di Cardiologia E Utic

Erice, TP, Italy

Location

Ospedale Santa Maria Dei Battuti - U.O. Di Cardiologia

Conegliano, TV, Italy

Location

Pou Santa Maria Della Misericordia - S.O.C. Cardiologia

Udine, UD, Italy

Location

Presidio Ospedaliero Di Saronno - U.O.C. Di Cardiologia

Saronno, VA, Italy

Location

Ospedale Civile - U.O. Cardiologia

Mirano, VE, Italy

Location

Ospedale Civile - U.O.C. Cardiologia

Arzignano, VI, Italy

Location

Ospedale Civile San Bortolo - U.O.C. Cardiologia

Vicenza, VI, Italy

Location

Casa Di Cura Dr. Pederzoli - Servizio Di Cardiologia

Peschiera del Garda, VR, Italy

Location

Ospedale Ss. Trinita' - S.C. Di Cardiologia

Borgomanero, Italy

Location

Ospedale San Leonardo - U.O. Di Cardiologia-Utic

Castellammare di Stabia, Italy

Location

Ospedale San Giovanni Di Dio - Uo Cardiologia - Utic

Frattamaggiore, Italy

Location

Ospedale Generale Di Zona - U.O. Cardiologia - Utic

Giugliano in Campania, Italy

Location

Ospedale Anna Rizzoli - Cardiologia-Utic

Lacco Ameno, Italy

Location

Aorn Cardarelli - U.O. Cardiologia Con Utic

Naples, Italy

Location

Clinica Mediterranea - U.O. Di Cardiologia

Naples, Italy

Location

Ospedale Del Mare - U.O. Cardiologia Con Utic

Naples, Italy

Location

Pres. Ospedaliero S. Maria Della Pieta' - U.O. Cardiologia E Utic

Nola, Italy

Location

Related Publications (1)

  • Gulizia MM, Fabbri G, Lucci D, Di Pasquale G, Gabrielli D, Campodonico J, Mauro A, Inciardi R, Di Lorenzo E, Oliva F, Nardi F, Colivicchi F, De Luca L; BLITZ-COVID19 Investigators. Type of hospitalisations and in-hospital outcomes in the Italian coronary care unit network at the time of COVID-19 pandemic: the BLITZ-COVID19 Registry. BMJ Open. 2022 Nov 29;12(11):e062382. doi: 10.1136/bmjopen-2022-062382.

Study Officials

  • Michele M Gulizia, MD

    Heart Care Foundation

    STUDY CHAIR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
OTHER
Target Duration
1 Day
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 2, 2021

First Posted

February 9, 2021

Study Start

November 9, 2020

Primary Completion

February 9, 2021

Study Completion

March 23, 2021

Last Updated

January 2, 2026

Record last verified: 2025-12

Locations